Title:
IN VITRO COMPOSITIONS COMPRISING HUMAN SAMPLE AND AMYLOID TARGETING AGENT
Document Type and Number:
WIPO Patent Application WO/2016/040891
Kind Code:
A3
Abstract:
Provided herein are compositions and methods useful for detection of amyloid related disorders in samples, such as human tissue, cell or body fluid. Use of the compositions and methods herein allows for the rapid, in vitro detection of amyloid accumulation, often before amyloid disorder symptoms are manifest or without introduction of foreign fluorophore molecules into a subject.
Inventors:
SARRAF STELLA (US)
Application Number:
PCT/US2015/049825
Publication Date:
May 06, 2016
Filing Date:
September 11, 2015
Export Citation:
Assignee:
AMYDIS DIAGNOSTICS (US)
International Classes:
C07D241/04; A61K35/00; C07D333/22; C07D401/04; C07D401/14; C07D405/04; C07D405/10; C07D407/10; C07D409/04; C07D409/10; C07D409/14; C07D413/10; C07D413/12; C07H19/056; G01N33/58
Domestic Patent References:
| WO2005040337A2 | 2005-05-06 | |||
| WO2008016682A2 | 2008-02-07 | |||
| WO2015143185A1 | 2015-09-24 | |||
| WO2011072257A2 | 2011-06-16 |
Foreign References:
| EP1431280A1 | 2004-06-23 |
Other References:
KEVIN CAO ET AL: "Amino Naphthalenyl-2-Cyano-Acrylate (ANCA) Probes Fluorescently Discriminate between Amyloid-[beta] and Prion Plaques in Brain", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1 January 2012 (2012-01-01), XP055034876, ISSN: 0002-7863, DOI: 10.1021/ja3063698
LISHENG CAI ET AL: "Radioligand Development for PET Imaging of [beta]-Amyloid (A[beta])-Current Status", CURRENT MEDICINAL CHEMISTRY, vol. 14, no. 1, 1 January 2007 (2007-01-01), NL, pages 19 - 52, XP055252033, ISSN: 0929-8673, DOI: 10.2174/092986707779313471
FURUMOTO SHOZO ET AL: "Recent advances in the development of amyloid imaging agents", CURRENT TOPICS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS LTD, HILVERSUM; NL, vol. 7, no. 18, 1 September 2007 (2007-09-01), pages 1773 - 1789, XP008150930, ISSN: 1568-0266, DOI: 10.2174/156802607782507402
MATHIS C A ET AL: "Synthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as amyloid Imaging Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 46, 19 June 2003 (2003-06-19), pages 2740 - 2754, XP002285914, ISSN: 0022-2623, DOI: 10.1021/JM030026B
I. A. BUHIMSCHI ET AL: "Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia", SCIENCE TRANSLATIONAL MEDICINE, vol. 6, no. 245, 16 July 2014 (2014-07-16), Washington, DC, pages 245ra92 - 245ra92, XP055256255, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3008808
LISHENG CAI ET AL: "Radioligand Development for PET Imaging of [beta]-Amyloid (A[beta])-Current Status", CURRENT MEDICINAL CHEMISTRY, vol. 14, no. 1, 1 January 2007 (2007-01-01), NL, pages 19 - 52, XP055252033, ISSN: 0929-8673, DOI: 10.2174/092986707779313471
FURUMOTO SHOZO ET AL: "Recent advances in the development of amyloid imaging agents", CURRENT TOPICS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS LTD, HILVERSUM; NL, vol. 7, no. 18, 1 September 2007 (2007-09-01), pages 1773 - 1789, XP008150930, ISSN: 1568-0266, DOI: 10.2174/156802607782507402
MATHIS C A ET AL: "Synthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as amyloid Imaging Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 46, 19 June 2003 (2003-06-19), pages 2740 - 2754, XP002285914, ISSN: 0022-2623, DOI: 10.1021/JM030026B
I. A. BUHIMSCHI ET AL: "Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia", SCIENCE TRANSLATIONAL MEDICINE, vol. 6, no. 245, 16 July 2014 (2014-07-16), Washington, DC, pages 245ra92 - 245ra92, XP055256255, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3008808
Attorney, Agent or Firm:
ANDERSON, Garrett et al. (650 Page Mill RoadPalo Alto, CA, US)
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