Title:
IN VIVO DELIVERY METHODS AND COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2002043806
Kind Code:
A3
Abstract:
Various methods are provided for determining and utilizing the viscosity of the circulating blood of a living being over a range of shear rates for diagnostics and treatment, such as detecting/reducing blood viscosity, work of the heart, contractility of the heart, for detecting/reducing the surface tension of the blood, for detecting plasma viscosity, for explaining/countering endothelial cell dysfunction, for providing high and low blood vessel wall shear stress data, red blood cell deformability data, lubricity of blood, and for treating different ailments such as peripheral arterial disease in combination with administering to a living being at least one pharmaceutically acceptable agent. Agents pharmaceutically effective to regulate at least one of the aforementioned blood parameters are used to adjust distribution of a substance through the bloodstream.
Inventors:
KENSEY KENNETH
HOKANSON CHARLES
HOKANSON CHARLES
Application Number:
PCT/US2001/044352
Publication Date:
March 27, 2003
Filing Date:
November 27, 2001
Export Citation:
Assignee:
RHEOLOGICS INC (US)
International Classes:
A61K31/00; A61K47/48; A61K49/00; A61M1/36; A61P7/00; A61P9/00; A61B5/029; (IPC1-7): A61P9/00; A61P7/00; A61K31/00
Domestic Patent References:
| WO2002009583A2 | 2002-02-07 | |||
| WO1999066839A1 | 1999-12-29 | |||
| WO1999010724A2 | 1999-03-04 | |||
| WO2001058356A2 | 2001-08-16 |
Foreign References:
| US5041430A | 1991-08-20 |
Other References:
MEDICAL RESEARCH COUNCIL'S GENERAL PRACTICE RESEARCH FRAMEWORK T: "Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk", LANCET, XX, XX, vol. 351, no. 9098, 24 January 1998 (1998-01-24), pages 233 - 241, XP004265259, ISSN: 0140-6736
ARMSTRONG J K ET AL: "COVALENT BINDING OF POLY(ETHYLENE GLYCOL) (PEG) TO THE SURFACE OF RED BLOOD CELLS INHIBITS AGGREGATION AND REDUCES LOW SHEAR BLOOD VISCOSITY", AMERICAN JOURNAL OF HEMATOLOGY, NEW YORK, NY, US, vol. 56, no. 1, September 1997 (1997-09-01), pages 26 - 28, XP000827783
ARMSTRONG J K ET AL: "COVALENT BINDING OF POLY(ETHYLENE GLYCOL) (PEG) TO THE SURFACE OF RED BLOOD CELLS INHIBITS AGGREGATION AND REDUCES LOW SHEAR BLOOD VISCOSITY", AMERICAN JOURNAL OF HEMATOLOGY, NEW YORK, NY, US, vol. 56, no. 1, September 1997 (1997-09-01), pages 26 - 28, XP000827783
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