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Title:
(INDAZOL-5-YL)-PYRAZINES AND (1,3-DIHYDRO-INDOL-2-ONE)- PYRAZINES FOR TREATING RHO KINASE-MEDIATED DISEASES AND CONDITIONS
Document Type and Number:
WIPO Patent Application WO2007076360
Kind Code:
A8
Abstract:
Methods for using (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines, are disclosed herein.

Inventors:
HELLBERG MARK R (US)
SHARIF NAJAM A (US)
MAY JESSE A (US)
RUSINKO ANDREW (US)
CHEN HWAMG-HSING (US)
Application Number:
PCT/US2006/062307
Publication Date:
December 06, 2007
Filing Date:
December 19, 2006
Export Citation:
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Assignee:
ALCON MFG LTD (US)
HELLBERG MARK R (US)
SHARIF NAJAM A (US)
MAY JESSE A (US)
RUSINKO ANDREW (US)
CHEN HWAMG-HSING (US)
International Classes:
A61K31/4965; C07D403/02
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