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Title:
INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2014/011900
Kind Code:
A3
Abstract:
Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.

Inventors:
BIFULCO NEIL JR (US)
BROOIJMANS NATASJA (US)
HODOUS BRIAN L (US)
KIM JOSEPH L (US)
MIDUTURU CHANDRASEKHAR V (US)
Application Number:
PCT/US2013/050106
Publication Date:
February 27, 2014
Filing Date:
July 11, 2013
Export Citation:
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Assignee:
BLUEPRINT MEDICINES (US)
International Classes:
A61K31/437; C07D239/42; A61K31/505; A61K31/506; A61K31/517; A61K31/519; C07D239/84; C07D471/04; C07D475/00; C07D487/04; A61P35/00
Domestic Patent References:
WO2004063195A12004-07-29
WO2009158571A12009-12-30
WO2010028236A12010-03-11
WO2011034907A22011-03-24
Other References:
ZHOU W ET AL: "A Structure-Guided Approach to Creating Covalent FGFR Inhibitors", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 17, no. 3, 26 March 2010 (2010-03-26), pages 285 - 295, XP026984442, ISSN: 1074-5521, [retrieved on 20100324]
Attorney, Agent or Firm:
McCARTY, Catherine, M. (Riverfront Office ParkOne Main Street, Suite 110, Cambridge MA, US)
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