Title:
INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION
Document Type and Number:
WIPO Patent Application WO/2021/080013
Kind Code:
A1
Abstract:
Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds and methods of using the compounds to treat disorders associated with dysregulation of TREK-1, TREK-2 or both TREK-1 and TREK-2 in a mammal.
Inventors:
LINDSLEY CRAIG W (US)
ENGERS DARREN W (US)
CHILDRESS ELIZABETH S (US)
BOLLINGER SEAN R (US)
SCHMITT JOZA (US)
CHOPKO TREVOR C (US)
DENTON JEROD S (US)
TANAKA MOTOYUKI (JP)
KURATA HARUTO (JP)
ENGERS DARREN W (US)
CHILDRESS ELIZABETH S (US)
BOLLINGER SEAN R (US)
SCHMITT JOZA (US)
CHOPKO TREVOR C (US)
DENTON JEROD S (US)
TANAKA MOTOYUKI (JP)
KURATA HARUTO (JP)
Application Number:
PCT/JP2020/039994
Publication Date:
April 29, 2021
Filing Date:
October 23, 2020
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
UNIV VANDERBILT (US)
UNIV VANDERBILT (US)
International Classes:
A61P21/00; A61K31/167; A61K31/27; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4965; A61K31/497; A61P21/02; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; C07C237/40; C07C237/42; C07C271/28; C07D213/75; C07D241/20; C07D401/04; C07D401/06; C07D401/12; C07D405/12; C07D405/14; C07D409/04; C07D413/04; C07D413/12; C07D413/14; C07D417/12
Domestic Patent References:
| WO2004048349A1 | 2004-06-10 | |||
| WO2008025540A1 | 2008-03-06 | |||
| WO2011002635A1 | 2011-01-06 | |||
| WO2019027855A1 | 2019-02-07 | |||
| WO2018110669A1 | 2018-06-21 | |||
| WO2014165307A2 | 2014-10-09 | |||
| WO2008012027A1 | 2008-01-31 |
Other References:
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DATABASE STN REGISTRY; 12 August 2012 (2012-08-12), ANONYMOUS: "Benzamide, N-[4-[(3-cyanophenyl)methoxy]-2-methylphenyl]-2-fluoro-5-methyl- (CA INDEX NAME)", XP055803741, retrieved from REGISTRY Database accession no. 1389969-77-0
CAS REGISTRY NO. 1390539-90-8, DATABASE REGISTRY, [online], 2012.08.13, [Retrieved on 2020.11.24], Retrieved from: STN Whole Document
LI MINGHONG, SHANG MING, XU HUI, WANG XING, DAI HUI-XIONG, YU JIN-QUAN: "Remote Para -C–H Acetoxylation of Electron-Deficient Arenes", ORGANIC LETTERS ., AMERICAN CHEMICAL SOCIETY, US, vol. 21, no. 2, 18 January 2019 (2019-01-18), US, pages 540 - 544, XP055803738, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b03871
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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