INJECTION FILLING MATERIAL AND PREPARATION PROCESS - GUANGZHOU YICHENG BIOTECH CO LTD

Title:

INJECTION FILLING MATERIAL AND PREPARATION PROCESS

Document Type and Number:

WIPO Patent Application WO/2022/142350

Kind Code:

A1

Abstract:

Disclosed are an injection filling material and a preparation process. The filling material comprises the following raw materials in terms of percentage by mass: 0.1-2% of sodium hyaluronate, 1-30% of polyester microspheres, 0.1-5% of silk fibroin, 0.01-1% of recombinant type III collagen, with the balance being a dispersion liquid. The polyester material is artificially synthesized; the sodium hyaluronate and recombinant protein are prepared by means of a fermentation method; the silk fibroin is extracted from secretions of mulberry silkworms instead of animal tissues, and compared with collagen extracted from animal tissues, a decellularized matrix is biologically safer; and the added polyester microspheres can produce a sustained-release effect on a system, prolong the duration of validity of the filling material, and the filling material lasts longer compared to a single-component material. The filling material comprises type I collagen (silk fibroin), type III collagen (recombinant protein) and a carbohydrate nutrient substance (hyaluronic acid), which are required for tissue production, and can provide a complete external environment for tissue production.

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Inventors:

JIN ZHENHUA (CN)
WANG LIJIE (CN)
OU JINGHUA (CN)

Application Number:

PCT/CN2021/111380

Publication Date:

July 07, 2022

Filing Date:

August 09, 2021

Export Citation:

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Assignee:

GUANGZHOU YICHENG BIOTECH CO LTD (CN)

International Classes:

A61L27/50; A61L27/18; A61L27/20; A61L27/22; A61L27/24

Foreign References:

CN112587721A	2021-04-02
CN110787319A	2020-02-14
US20140308362A1	2014-10-16
CN105126166A	2015-12-09
CN111184909A	2020-05-22
CN109621003A	2019-04-16
CN104258470A	2015-01-07
US20090035251A1	2009-02-05

Attorney, Agent or Firm:

GUANGZHOU ZHISHUN INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)

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