Title:
INOSINE AS BIOMARKER FOR ALZHEIMER'S DISEASE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/035467
Kind Code:
A1
Abstract:
A biomarker for Alzheimer's disease and the use thereof. The biomarker for Alzheimer's disease is inosine. It is detected for the first time that the level of inosine in a stool sample of a patient with Alzheimer's disease is significantly lower than that in a stool sample of a normal person. Inosine in the stool serves as the biomarker for Alzheimer's disease, and the early diagnosis of Alzheimer's disease can be assisted by detecting the level of inosine in the stool, which facilitates non-invasive and rapid detection, and has the characteristics of timeliness, convenience, high specificity and high sensitivity.
Inventors:
CHEN YU (CN)
CHEN YIJING (CN)
FAN YINGYING (CN)
CHEN YUEWEN (CN)
YE TAO (CN)
XU JINYING (CN)
CHEN YIJING (CN)
FAN YINGYING (CN)
CHEN YUEWEN (CN)
YE TAO (CN)
XU JINYING (CN)
Application Number:
PCT/CN2021/138120
Publication Date:
March 16, 2023
Filing Date:
December 14, 2021
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
G01N30/02; G01N33/68
Domestic Patent References:
| WO2008154415A1 | 2008-12-18 |
Foreign References:
| CN111413424A | 2020-07-14 | |||
| CN107667293A | 2018-02-06 | |||
| CN107449831A | 2017-12-08 | |||
| CN110333310A | 2019-10-15 | |||
| US20090099783A1 | 2009-04-16 | |||
| JP2011242217A | 2011-12-01 |
Other References:
ANSOLEAGA BELÉN; JOVÉ MARIONA; SCHLÜTER AGATHA; GARCIA-ESPARCIA PAULA; MORENO JESÚS; PUJOL AURORA; PAMPLONA REINALD; PORTERO-OTÍN : "Deregulation of purine metabolism in Alzheimer's disease", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 36, no. 1, 8 August 2014 (2014-08-08), US , pages 68 - 80, XP029115010, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2014.08.004
ZHOU HONGXU, TAI JINGJIE, XU HAIYAN, LU XIUMEI, MENG DALI: "Xanthoceraside Could Ameliorate Alzheimer’s Disease Symptoms of Rats by Affecting the Gut Microbiota Composition and Modulating the Endogenous Metabolite Levels", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 10, 13 September 2019 (2019-09-13), CH , pages 1035 - 15, XP093046233, ISSN: 1663-9812, DOI: 10.3389/fphar.2019.01035
LIANG QUN, LIU HAN, ZHANG TIANYU, JIANG YAN, XING HAITAO, ZHANG AI-HUA: "Metabolomics-based screening of salivary biomarkers for early diagnosis of Alzheimer's disease", RSC ADVANCES, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 5, no. 116, 1 January 2015 (2015-01-01), GB , pages 96074 - 96079, XP093046234, ISSN: 2046-2069, DOI: 10.1039/C5RA19094K
ALONSO-ANDRÉS PATRICIA, ALBASANZ JOSÉ LUIS, FERRER ISIDRO, MARTÍN MAIRENA: "Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology : Purine-related Metabolites and their Converting Enzymes in AD", BRAIN PATHOLOGY., ZUERICH, CH, vol. 28, no. 6, 1 November 2018 (2018-11-01), CH , pages 933 - 946, XP055982213, ISSN: 1015-6305, DOI: 10.1111/bpa.12592
ZHOU HONGXU, TAI JINGJIE, XU HAIYAN, LU XIUMEI, MENG DALI: "Xanthoceraside Could Ameliorate Alzheimer’s Disease Symptoms of Rats by Affecting the Gut Microbiota Composition and Modulating the Endogenous Metabolite Levels", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 10, 13 September 2019 (2019-09-13), CH , pages 1035 - 15, XP093046233, ISSN: 1663-9812, DOI: 10.3389/fphar.2019.01035
LIANG QUN, LIU HAN, ZHANG TIANYU, JIANG YAN, XING HAITAO, ZHANG AI-HUA: "Metabolomics-based screening of salivary biomarkers for early diagnosis of Alzheimer's disease", RSC ADVANCES, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 5, no. 116, 1 January 2015 (2015-01-01), GB , pages 96074 - 96079, XP093046234, ISSN: 2046-2069, DOI: 10.1039/C5RA19094K
ALONSO-ANDRÉS PATRICIA, ALBASANZ JOSÉ LUIS, FERRER ISIDRO, MARTÍN MAIRENA: "Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology : Purine-related Metabolites and their Converting Enzymes in AD", BRAIN PATHOLOGY., ZUERICH, CH, vol. 28, no. 6, 1 November 2018 (2018-11-01), CH , pages 933 - 946, XP055982213, ISSN: 1015-6305, DOI: 10.1111/bpa.12592
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
Download PDF:
Previous Patent: INFORMATION MARKING SYSTEM
Next Patent: ALZHEIMER'S DISEASE BIOMARKER L-VALINE AND APPLICATION THEREOF
Next Patent: ALZHEIMER'S DISEASE BIOMARKER L-VALINE AND APPLICATION THEREOF