Title:
INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS
Document Type and Number:
WIPO Patent Application WO/2017/222556
Kind Code:
A3
Abstract:
This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified α1-α2 domains of NKG2D ligands. This application further relates to modified α1-α2 domains of NKG2D ligands attached to polypeptides, in some embodiments antibodies or fragments of antibodies. This application further relates to antigen-binding peptides derived from light and heavy chain antibody variable domains, which contain two linker regions and a split variable domain.
Inventors:
LANDGRAF KYLE (US)
STEIGER DANIEL P (US)
WILLIAMS STEVEN R (US)
MARTIN DAVID W (US)
GEBHART DANA (US)
BARON TARAH (US)
STEIGER DANIEL P (US)
WILLIAMS STEVEN R (US)
MARTIN DAVID W (US)
GEBHART DANA (US)
BARON TARAH (US)
Application Number:
PCT/US2016/039281
Publication Date:
April 19, 2018
Filing Date:
June 24, 2016
Export Citation:
Assignee:
AVIDBIOTICS CORP (US)
International Classes:
C07K16/28; A61K39/395; C07K14/74; C07K16/32; C07K19/00; C12N15/62
Domestic Patent References:
| WO2016090278A2 | 2016-06-09 | |||
| WO2017024131A1 | 2017-02-09 |
Foreign References:
| US20150165065A1 | 2015-06-18 | |||
| CN104592395A | 2015-05-06 | |||
| US20110311561A1 | 2011-12-22 |
Other References:
DATABASE Geneseq [online] 2 February 2012 (2012-02-02), "Human MHC class I chain-related MICB soluble protein, SEQ ID 9.", XP002776388, retrieved from EBI accession no. GSP:AZQ72393 Database accession no. AZQ72393
CANDICE S. E. LENGYEL ET AL: "Mutations Designed to Destabilize the Receptor-Bound Conformation Increase MICA-NKG2D Association Rate and Affinity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 42, 19 October 2007 (2007-10-19), pages 30658 - 30666, XP055432102, ISSN: 0021-9258, DOI: 10.1074/jbc.M704513200
CANDICE S. E. LENGYEL ET AL: "Mutations Designed to Destabilize the Receptor-Bound Conformation Increase MICA-NKG2D Association Rate and Affinity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 42, 19 October 2007 (2007-10-19), pages 30658 - 30666, XP055432102, ISSN: 0021-9258, DOI: 10.1074/jbc.M704513200
Attorney, Agent or Firm:
MACK, Susan J. et al. (US)
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