Title:
INTEGRIN ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2001062905
Kind Code:
A3
Abstract:
The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration, and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin domains and methods for using said compositions. In preferred embodiments the methods and compositions of the invention are used to inhibit angiogenesis and to treat diseases or conditions mediated by angiogenesis.
Inventors:
FANSLOW WILLIAM C III (US)
CERRETTI DOUGLAS PAT (US)
POINDEXTER KURT MATTHEW (US)
BLACK ROY ALVIN (US)
CERRETTI DOUGLAS PAT (US)
POINDEXTER KURT MATTHEW (US)
BLACK ROY ALVIN (US)
Application Number:
PCT/US2001/005701
Publication Date:
March 21, 2002
Filing Date:
February 23, 2001
Export Citation:
Assignee:
IMMUNEX CORP (US)
FANSLOW WILLIAM C III (US)
CERRETTI DOUGLAS PAT (US)
POINDEXTER KURT MATTHEW (US)
BLACK ROY ALVIN (US)
FANSLOW WILLIAM C III (US)
CERRETTI DOUGLAS PAT (US)
POINDEXTER KURT MATTHEW (US)
BLACK ROY ALVIN (US)
International Classes:
C12N15/09; A61K38/00; A61K45/00; A61K51/00; A61P1/04; A61P3/10; A61P7/02; A61P9/10; A61P17/02; A61P17/06; A61P19/02; A61P19/10; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P35/00; A61P35/04; A61P43/00; C07K14/46; C07K14/705; C07K19/00; C12N9/64; C12N15/57; C12P21/02; C12Q1/02; (IPC1-7): C12N9/64; C12N15/57; A61K38/16; A61P35/00; A61P37/00; A61P27/00; A61P17/02; C07K14/705
Domestic Patent References:
| WO1999041388A2 | 1999-08-19 | |||
| WO1999023228A1 | 1999-05-14 | |||
| WO1999036549A1 | 1999-07-22 | |||
| WO2000043493A2 | 2000-07-27 | |||
| WO2001074857A2 | 2001-10-11 |
Other References:
SCHLUESENER HERMANN J: "The disintegrin domain of ADAM 8 enhances protection against rat experimental autoimmune encephalomyelitis, neuritis and uveitis by a polyvalent autoantigen vaccine.", JOURNAL OF NEUROIMMUNOLOGY, vol. 87, no. 1-2, 1 July 1998 (1998-07-01), pages 197 - 202, XP000926791, ISSN: 0165-5728
NATH DEEPA ET AL: "Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells.", JOURNAL OF CELL SCIENCE, vol. 112, no. 4, February 1999 (1999-02-01), LONDON GB, pages 579 - 587, XP002186267, ISSN: 0021-9533
ZHANG XI-PING ET AL: "Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 13, 27 March 1998 (1998-03-27), WASHINGTON US, pages 7345 - 7350, XP002186268, ISSN: 0021-9258
SHEU J-R ET AL: "Inhibition of angiogenesis in vitro and in vivo: comparison of the relative activities of triflavin, an Arg-Gly-Asp-containing peptide and anti-alphavbeta3 integrin monoclonal antibody", BBA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 1336, no. 3, 20 October 1997 (1997-10-20), pages 445 - 454, XP004276037, ISSN: 0304-4165
TSELEPIS VICKY H ET AL: "An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity: Evidence for a functional equivalence of acidic integrin-binding motifs", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 34, 1997, pages 21341 - 21348, XP002149905, ISSN: 0021-9258
NATH DEEPA ET AL: "Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells.", JOURNAL OF CELL SCIENCE, vol. 112, no. 4, February 1999 (1999-02-01), LONDON GB, pages 579 - 587, XP002186267, ISSN: 0021-9533
ZHANG XI-PING ET AL: "Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 13, 27 March 1998 (1998-03-27), WASHINGTON US, pages 7345 - 7350, XP002186268, ISSN: 0021-9258
SHEU J-R ET AL: "Inhibition of angiogenesis in vitro and in vivo: comparison of the relative activities of triflavin, an Arg-Gly-Asp-containing peptide and anti-alphavbeta3 integrin monoclonal antibody", BBA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 1336, no. 3, 20 October 1997 (1997-10-20), pages 445 - 454, XP004276037, ISSN: 0304-4165
TSELEPIS VICKY H ET AL: "An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity: Evidence for a functional equivalence of acidic integrin-binding motifs", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 34, 1997, pages 21341 - 21348, XP002149905, ISSN: 0021-9258
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