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Patent Searching and Data


Title:
INTEGRIN ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2018/132268
Kind Code:
A8
Abstract:
The present disclosure provides pharmaceutical agents, including those of the formula:(I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ανβι and/or α5βι. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ανβ3, ανβ5, ανβ6, ανβ8, and/or αIIbβ3.

Inventors:
RUMINSKI PETER (US)
GRIGGS DAVID (US)
SEIWERT SCOTT (US)
Application Number:
PCT/US2017/068801
Publication Date:
June 20, 2019
Filing Date:
December 28, 2017
Export Citation:
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Assignee:
UNIV SAINT LOUIS (US)
INDALO THERAPEUTICS INC (US)
International Classes:
C07D471/04; A61K31/4375; A61P9/00; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P43/00
Attorney, Agent or Firm:
ALTMAN, Daniel, E. (US)
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