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Title:
INTERMEDIATE IN PRODUCTION OF [2-(3,3,5,5-TETRAMETHYLCYCLOHEXYL)PHENYL]PIPERAZINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2006/126635
Kind Code:
A1
Abstract:
A compound represented by the general formula below or a salt thereof is a useful intermediate in the production of a [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound that has excellent cell adhesion inhibitory effect and cell invasion inhibitory effect and therefore is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases induced by the adhesion and invasion of leukocytes, such as inflammatory bowel diseases (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. [Chemical formulae] wherein R1 and R2 independently represent a hydrogen atom or an amino-protecting group for an amino group, or R1 and R2 may together form a pyrrole ring which may have a substituent.

Inventors:
NAGAI MITSUO (JP)
NARA KAZUMASA (JP)
WAKASUGI KAZUNORI (JP)
NAITO TOSHIHIKO (JP)
Application Number:
PCT/JP2006/310450
Publication Date:
November 30, 2006
Filing Date:
May 25, 2006
Export Citation:
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Assignee:
EISAI R&D MAN CO LTD (JP)
NAGAI MITSUO (JP)
NARA KAZUMASA (JP)
WAKASUGI KAZUNORI (JP)
NAITO TOSHIHIKO (JP)
International Classes:
C07C211/45; C07C233/25; C07C275/32; C07D295/02
Domestic Patent References:
WO2005063705A12005-07-14
WO2006068058A12006-06-29
Other References:
FLEMING I. ET AL.: "Two new oxindole syntheses", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, no. 2, 1986, pages 349 - 359, XP009071954
See also references of EP 1889827A4
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Ginza First Bldg. 10-6, Ginza 1-chom, Chuo-ku Tokyo 61, JP)
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