Title:
INTERMEDIATE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/127320
Kind Code:
A1
Abstract:
An application of an intermediate or a preparation method therefor in total synthesis of a morphine derivative. On the basis of a possible biogenic pathway of morphine derivatives, efficient production of morphine derivatives, especially representative oxycodone and codeine, is implemented by means of a biomimetic synthesis strategy by using a transition metal-catalyzed asymmetric hydrogenation reaction and an intramolecular oxidative dearomatization Heck reaction in the process of preparing the intermediate as key reactions of total synthesis.
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Inventors:
QIN YONG (CN)
ZHONG WU (CN)
LI SONG (CN)
SONG HAO (CN)
LIU XIAOYU (CN)
LI WENFEI (CN)
ZHOU XIAOHAN (CN)
ZHOU RUIJIE (CN)
XUE FEI (CN)
ZHANG DAN (CN)
ZHENG ZHIBING (CN)
ZHONG WU (CN)
LI SONG (CN)
SONG HAO (CN)
LIU XIAOYU (CN)
LI WENFEI (CN)
ZHOU XIAOHAN (CN)
ZHOU RUIJIE (CN)
XUE FEI (CN)
ZHANG DAN (CN)
ZHENG ZHIBING (CN)
Application Number:
PCT/CN2021/123641
Publication Date:
June 23, 2022
Filing Date:
October 13, 2021
Export Citation:
Assignee:
UNIV SICHUAN (CN)
International Classes:
C07D489/02; C07D217/20; C07D221/28; C07D489/08
Domestic Patent References:
| WO2020085234A1 | 2020-04-30 |
Foreign References:
| CN101955484A | 2011-01-26 | |||
| CN102459275A | 2012-05-16 | |||
| CN109666030A | 2019-04-23 | |||
| CN106029669A | 2016-10-12 | |||
| CN107964030A | 2018-04-27 | |||
| CN111205296A | 2020-05-29 |
Other References:
LIPP ALEXANDER, SELT MAXIMILIAN, FERENC DOROTA, SCHOLLMEYER DIETER, WALDVOGEL SIEGFRIED R., OPATZ TILL: "Total Synthesis of (−)-Oxycodone via Anodic Aryl–Aryl Coupling", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 21, no. 6, 15 March 2019 (2019-03-15), US , pages 1828 - 1831, XP055944286, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.9b00419
ZHANG TAO, WU ZENONG, CHEN YIBO, ZHAO WEILI, YANG ZHEZHOU, ZHANG FULI: "One-Pot Process for Synthesis of Nalbuphine Hydrochloride and Impurity Control Strategy", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 24, no. 9, 18 September 2020 (2020-09-18), US , pages 1707 - 1717, XP055944288, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.0c00321
ZHANG TAO, WU ZENONG, CHEN YIBO, ZHAO WEILI, YANG ZHEZHOU, ZHANG FULI: "One-Pot Process for Synthesis of Nalbuphine Hydrochloride and Impurity Control Strategy", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 24, no. 9, 18 September 2020 (2020-09-18), US , pages 1707 - 1717, XP055944288, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.0c00321
Attorney, Agent or Firm:
CHENGDU JEWEIHO INTELLECTUAL PROPERTY LAW FIRM (CN)
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