Title:
ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/068698
Kind Code:
A1
Abstract:
Disclosed are compounds inhibiting the conversion of α–KG to D-2-HG, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat IDH associated diseases, including cancer.
Inventors:
YANG JIBIN (CN)
YAN FENG (CN)
ZHU JINLONG (CN)
YANG JIANXIN (US)
YAN FENG (CN)
ZHU JINLONG (CN)
YANG JIANXIN (US)
Application Number:
PCT/CN2020/113945
Publication Date:
April 15, 2021
Filing Date:
September 08, 2020
Export Citation:
Assignee:
SHANGHAI METON PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61P35/00
Domestic Patent References:
| WO2018010637A1 | 2018-01-18 | |||
| WO2008136756A1 | 2008-11-13 | |||
| WO2016171755A1 | 2016-10-27 | |||
| WO2010139953A1 | 2010-12-09 |
Other References:
DATABASE STN REGISTRY REGISTRY; 2 September 2020 (2020-09-02), ANONYMOUS: "1H-Isoindol-1-one, 4-[[(1,6-dihydro-1-methyl-6-oxo-3- pyridinyl)methyl]amino]-2,3-dihydro-2-methyl- (CA INDEX NAME)", XP055800036, retrieved from REGISTRY Database accession no. 2470419-22-6 (2467859-28-3，2467645-59-4，2467447-17-0 et al.)
See also references of EP 4041732A4
See also references of EP 4041732A4
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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