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Title:
ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/064002
Kind Code:
A1
Abstract:
The present invention relates to a polysubstituted isoindoline compound as shown in general formula (I), and a preparation method, a pharmaceutical composition and the use thereof. In particular, the polysubstituted isoindoline compound is provided in the present invention as a class of novel CRL4CRBN E3 ubiquitin ligase modulators in structure, wherein same has a stronger antitumor activity and antitumor spectrum, and can be used to prepare drugs for treating CRL4CRBN E3 ligase-related diseases.

Inventors:
CHEN XIAOHUA (CN)
LI JIA (CN)
CHENG YU (CN)
ZHOU YUBO (CN)
NIE HUIJUN (CN)
WANG YUJIE (CN)
TIAN HONGTAO (CN)
KAN WEIJUAN (CN)
MI TIAN (CN)
HU XIAOBEI (CN)
ZHOU BINSHAN (CN)
YAN KENIAN (CN)
XU GAOYA (CN)
ZHONG YUHUA (CN)
FENG LEI (CN)
Application Number:
PCT/CN2019/109368
Publication Date:
April 02, 2020
Filing Date:
September 30, 2019
Export Citation:
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Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K31/45; C07D401/14; A61K31/454; A61K31/4545; A61K31/497; A61K31/538; A61P25/00; A61P29/00; A61P35/00; A61P37/00; C07D401/04; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D419/14; C07D487/10; C07D491/107; C07D498/10
Domestic Patent References:
WO2019133531A12019-07-04
WO2018119448A12018-06-28
WO2008115516A22008-09-25
WO2011100380A12011-08-18
WO2016065980A12016-05-06
WO2007027527A22007-03-08
WO2008027542A22008-03-06
Foreign References:
CN101679380A2010-03-24
CN105566290A2016-05-11
CN102822165A2012-12-12
CN101291924A2008-10-22
US8153659B22012-04-10
US9181216B22015-11-10
US9920027B22018-03-20
CN102822165A2012-12-12
CN105566290A2016-05-11
US10017492B22018-07-10
CN101291924A2008-10-22
US8481568B22013-07-09
US8877780B22014-11-04
US9447070B22016-09-20
Other References:
LOHBECK, JASMIN: "Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19 September 2016 (2016-09-19), pages 5260 - 5262, XP029775015
PAPATZIMAS, JAMES W.: "A General Strategy for the Preparation of Thalido- mide-Conjugate Linkers", SYNLETT, vol. 28, no. 20, 23 August 2017 (2017-08-23), pages 2881 - 2885, XP055617232
See also references of EP 3862348A4
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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