Title:
ISOLATED COMPOUNDS FROM PHALERIA MACROCARPA AS ANTI-CANCER AGENTS
Document Type and Number:
WIPO Patent Application WO/2010/064172
Kind Code:
A3
Abstract:
The invention concerns compounds DLBS1425E2.2 and DLBS1425F1 isolated and identified from the extract of the plant Phaleria macrocarpa (Scheff.) Boerl. The invention also relates to the use of said compounds, either as a single active compound or in combination, in a pharmaceutical dosage form that has anti-proliferative activity of cancer cells, and its use relating to female related diseases. Formula (I).
Inventors:
ARIPIN ASEP (ID)
ARIFIN POPPY FIRZANI (ID)
TJANDRAWINATA RAYMOND R (ID)
ARIFIN POPPY FIRZANI (ID)
TJANDRAWINATA RAYMOND R (ID)
Application Number:
PCT/IB2009/055353
Publication Date:
September 02, 2010
Filing Date:
November 26, 2009
Export Citation:
Assignee:
PT DEXA MEDICA (ID)
ARIPIN ASEP (ID)
ARIFIN POPPY FIRZANI (ID)
TJANDRAWINATA RAYMOND R (ID)
ARIPIN ASEP (ID)
ARIFIN POPPY FIRZANI (ID)
TJANDRAWINATA RAYMOND R (ID)
International Classes:
A61K31/12; C07C49/245; A61K31/7034; A61K36/83; A61P35/00; C07H15/203
Domestic Patent References:
| WO2009153692A1 | 2009-12-23 |
Other References:
OSHIMI S. ET AL: "Studies on the constituents from the fruits of Phaleria macrocarpa", JOURNAL OF NATURAL MEDICINE, vol. 62, 2008, pages 207 - 210, XP008137409
TSUKAMOTO S. ET AL: "7-Hydroxy-3-(4-hydroxybenzyl)chroman and Broussonin B: Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides BUNGE, Function as Proteasome Inhibitors", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 28, no. 9, 2005, pages 1798 - 1800, XP007905864
MATSUDA H. ET AL: "Testosterone 5a-Reductase Inhibitory Active Constituents from Anemarrhenae Rhizoma", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 24, no. 5, 2001, pages 586 - 587, XP008158463
FERRARI J. ET AL: "Benzophenone glycosides from Gnidia involucrate", PHYTOCHEMISTRY, vol. 54, 2000, pages 883 - 889, XP027253762
DATABASE CA XP008158471, Database accession no. 1996:345028
NIKAIDO T. ET AL: "Inhibitors of Cyclic AMP Phosphodiesterase in Medicinal Plants", PLANTA MEDICA, vol. 43, 1981, pages 18 - 23, XP009164100
CORREA D. ET AL: "Duckein, an Alkaloid from Aniba duckei", PHYTOCHEMISTRY, vol. 14, 1975, pages 271 - 272, XP008158464
FARIED A. ET AL: "Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 30, 2007, pages 605 - 613, XP008137412
MAE S.H.W. ET AL: "Phalerin, a new benzophenoic glucoside isolated from the methanolic extract of Mahkota Dewa [Phaleria macrocarpa (scheff). Boerl.] leaves", MAJALAH FARMASI INDONESIA, vol. 16, no. 1, 2005, pages 51 - 57, XP008158467
TAMBUNAN R.M. ET AL: "Determination of chemical structure of antioxidant compound benzophenon glycoside from n-butanolextract of the fruits of Mahkota Dewa [Phaleria macrocarpa (Scheff) Boerl.]", MAJALAH FARMASI INDONESIA, vol. 17, no. 4, 2006, pages 184 - 189, XP008158469
HENDRA P. ET AL: "Synthesis of Benzophenone Glucopyranosides from Phaleria macrocarpa and Related Benzophenone Glucopyranosides", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 73, no. 10, 2009, pages 2172 - 2182, XP008158465
YOUN U.J. ET AL: "Identification of Antiadipogenic Constituents of the Rhizomes of Anemarrhena asphodeloides", JOURNAL OF NATURAL PRODUCTS, vol. 72, 2009, pages 1895 - 1898, XP008158466
TSUKAMOTO S. ET AL: "7-Hydroxy-3-(4-hydroxybenzyl)chroman and Broussonin B: Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides BUNGE, Function as Proteasome Inhibitors", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 28, no. 9, 2005, pages 1798 - 1800, XP007905864
MATSUDA H. ET AL: "Testosterone 5a-Reductase Inhibitory Active Constituents from Anemarrhenae Rhizoma", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 24, no. 5, 2001, pages 586 - 587, XP008158463
FERRARI J. ET AL: "Benzophenone glycosides from Gnidia involucrate", PHYTOCHEMISTRY, vol. 54, 2000, pages 883 - 889, XP027253762
DATABASE CA XP008158471, Database accession no. 1996:345028
NIKAIDO T. ET AL: "Inhibitors of Cyclic AMP Phosphodiesterase in Medicinal Plants", PLANTA MEDICA, vol. 43, 1981, pages 18 - 23, XP009164100
CORREA D. ET AL: "Duckein, an Alkaloid from Aniba duckei", PHYTOCHEMISTRY, vol. 14, 1975, pages 271 - 272, XP008158464
FARIED A. ET AL: "Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 30, 2007, pages 605 - 613, XP008137412
MAE S.H.W. ET AL: "Phalerin, a new benzophenoic glucoside isolated from the methanolic extract of Mahkota Dewa [Phaleria macrocarpa (scheff). Boerl.] leaves", MAJALAH FARMASI INDONESIA, vol. 16, no. 1, 2005, pages 51 - 57, XP008158467
TAMBUNAN R.M. ET AL: "Determination of chemical structure of antioxidant compound benzophenon glycoside from n-butanolextract of the fruits of Mahkota Dewa [Phaleria macrocarpa (Scheff) Boerl.]", MAJALAH FARMASI INDONESIA, vol. 17, no. 4, 2006, pages 184 - 189, XP008158469
HENDRA P. ET AL: "Synthesis of Benzophenone Glucopyranosides from Phaleria macrocarpa and Related Benzophenone Glucopyranosides", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 73, no. 10, 2009, pages 2172 - 2182, XP008158465
YOUN U.J. ET AL: "Identification of Antiadipogenic Constituents of the Rhizomes of Anemarrhena asphodeloides", JOURNAL OF NATURAL PRODUCTS, vol. 72, 2009, pages 1895 - 1898, XP008158466
Attorney, Agent or Firm:
ROSALINA, Belinda (Jakarta Selatan, ID)
Download PDF:
Previous Patent: COAXIALLY ENCAPSULATED CELL SUSPENSIONS AND MICROTISSUES
Next Patent: A METHOD FOR TRANSMITTING ADVERTISEMENTS
Next Patent: A METHOD FOR TRANSMITTING ADVERTISEMENTS