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Title:
ISOLATED HUMAN TRANSPORTER PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN TRANSPORTER PROTEINS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002033086
Kind Code:
A3
Abstract:
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.

Inventors:
MERKULOV GENNADY V
KETCHUM KAREN A
SHAO WEI
YAN CHUNHUA
DI FRANCESCO VALENTINA
BEASLEY ELLEN M
Application Number:
PCT/US2001/032152
Publication Date:
March 27, 2003
Filing Date:
October 17, 2001
Export Citation:
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Assignee:
PE CORP NY (US)
International Classes:
A01K67/027; A61K45/00; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; (IPC1-7): C12N15/12; A01K67/027; C07K14/47; C07K14/705; C07K16/18; C07K16/28; C12N1/21; C12N5/10; C12N15/63; C12Q1/68; G01N33/68
Domestic Patent References:
WO2000058473A22000-10-05
WO2001083744A22001-11-08
Foreign References:
Other References:
KRAEV A ET AL: "The organization of the human gene NCX1 encoding the sodium-calcium exchanger", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 37, no. 1, 1996, pages 105 - 112, XP002181613, ISSN: 0888-7543
NICOLL D A ET AL: "Cloning of a third mammalian Na+-Ca-2+ exchanger, NCX3", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,, US, vol. 271, no. 40, 4 October 1996 (1996-10-04), pages 24914 - 24921, XP002181612, ISSN: 0021-9258
DATABASE EMBL [online] 1 September 1999 (1999-09-01), BIRREN B ET AL: "Homo sapiens clone RP11-1I11, WORKING DRAFT SEQUENCE, 31 unordered pieces.", XP002210609, Database accession no. AC009607
DATABASE EMBL [online] 13 March 2000 (2000-03-13), HEILIG R ET AL: "Human chromosome 14 DNA sequence BAC R-486O13 of library RPCI-11 from chromosome 14 of Homo sapiens (Human)", XP002210610, Database accession no. AL160191
DATABASE EMBL [online] 6 June 2001 (2001-06-06), BORTOLUZZI S: "Homo sapiens mRNA for sodium/calcium exchanger, SCL8A3, alternative splice form B (SCL8A3 gene)", XP002210611, Database accession no. AJ304853; Q96QG1
KOMURO I ET AL: "MOLECULAR CLONING AND CHARACTERIZATION OF THE HUMAN CARDIAC SODIUM CALCIUM EXCHANGER CDNA", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 89, no. 10, 1992, 1992, pages 4769 - 4773, XP002210606, ISSN: 0027-8424
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