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Title:
ISOQUINOLINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/162274
Kind Code:
A1
Abstract:
The chemical compounds represented by formula (I) and the pharmaceutically acceptable salt thereof have CRTH2-inhibiting activity, and are useful compounds for pharmaceutical products.

Inventors:
TAKAYAMA TETSUO (JP)
KAWAMURA MADOKA (JP)
WAKASUGI DAISUKE (JP)
NISHIKAWA RIE (JP)
SEKIGUCHI YOSHINORI (JP)
Application Number:
PCT/JP2011/064208
Publication Date:
December 29, 2011
Filing Date:
June 22, 2011
Export Citation:
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Assignee:
TAISHO PHARMA CO LTD (JP)
TAKAYAMA TETSUO (JP)
KAWAMURA MADOKA (JP)
WAKASUGI DAISUKE (JP)
NISHIKAWA RIE (JP)
SEKIGUCHI YOSHINORI (JP)
International Classes:
C07D217/18; A61K31/472; A61P11/02; A61P11/06; A61P17/04; A61P37/08; A61P43/00; C07D217/20
Domestic Patent References:
WO2004101528A22004-11-25
WO2009060209A12009-05-14
WO2010074244A12010-07-01
WO2005019171A12005-03-03
WO2005115382A12005-12-08
WO2004096777A12004-11-11
WO2004101528A22004-11-25
Foreign References:
EP0030861A21981-06-24
Other References:
See also references of EP 2586772A4
NAGATA ET AL., J. IMMUNOL., vol. 162, 1999, pages 1278
DEL PRETE ET AL., ALLERGY, vol. 47, 1992, pages 450
POPE ET AL., J. ALLERGY. CLIN. IMMUNOL., vol. 108, 2001, pages 594
MIN ET AL., CURR. OPIN. HEMATOL., vol. 15, 2008, pages 59
BROIDE ET AL., J. ALLERGY. CLIN. IMMUNOL., vol. 108, no. 2, 2001, pages S65
ABE ET AL., GENE, vol. 227, 1999, pages 71
HIRAI ET AL., J. EXP. MED., vol. 193, 2001, pages 225
SHIRAISHI ET AL., J. PHARMACOL. EXP. THER., vol. 312, 2005, pages 954
SATOH ET AL., J. IMMUNOL., vol. 177, 2006, pages 2621
KANO ET AL., AM. J. RHINOL., vol. 20, 2006, pages 342
P. G. M. WUTS; T. GREEN: "Protective Groups in Organic Synthesis, third edition", 1999
Attorney, Agent or Firm:
ASAMURA Kiyoshi et al. (JP)
Hiroshi Asamura (JP)
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