Title:
ISOQUINOLINONE COMPOUND AND USE THEREOF IN PREPARATION OF ANTIVIRAL DRUGS
Document Type and Number:
WIPO Patent Application WO/2018/019297
Kind Code:
A1
Abstract:
Disclosed is an isoquinolinone compound as shown in formula (I) or a stereoisomer, pharmaceutically acceptable salt, solvate or crystal thereof, and a preparation thereof and a use thereof in the preparation of drugs for treating or preventing viral infectious diseases caused by the hepatitis B virus (HBV) and other viruses, in particular, a use thereof in drugs for HBV Surface antigen inhibitors and HBV DNA production inhibitors. The compound has a significant activity for inhibiting the hepatitis B surface antigen and hepatitis B DNA, and it is possible to significantly improve the probability of curing hepatitis B by administration of same in combination with nucleoside drugs or other drugs in the future, and same has good clinical application prospects.
Inventors:
CHEN LI (CN)
ZHAI PEIBIN (CN)
SHAO QING (CN)
WU JIN (CN)
JIANG TAO (CN)
LI XIAOWEN (CN)
ZHAI PEIBIN (CN)
SHAO QING (CN)
WU JIN (CN)
JIANG TAO (CN)
LI XIAOWEN (CN)
Application Number:
PCT/CN2017/094946
Publication Date:
February 01, 2018
Filing Date:
July 28, 2017
Export Citation:
Assignee:
GINKGO PHARMA CO LTD (CN)
International Classes:
C07D455/06; A61K31/4375; A61K31/5365; A61K31/542; A61P31/20; C07D471/04; C07D491/048; C07D491/056; C07D498/04; C07D513/04
Domestic Patent References:
WO2015113990A1 | 2015-08-06 | |||
WO2016071215A1 | 2016-05-12 | |||
WO2017017042A1 | 2017-02-02 |
Foreign References:
CN106810548A | 2017-06-09 |
Other References:
See also references of EP 3492467A4
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT & TRADEMARK AGENCY LTD. (CN)
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