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Title:
ISOQUINOLINONE COMPOUND AND USE THEREOF IN PREPARATION OF ANTIVIRAL DRUGS
Document Type and Number:
WIPO Patent Application WO/2018/019297
Kind Code:
A1
Abstract:
Disclosed is an isoquinolinone compound as shown in formula (I) or a stereoisomer, pharmaceutically acceptable salt, solvate or crystal thereof, and a preparation thereof and a use thereof in the preparation of drugs for treating or preventing viral infectious diseases caused by the hepatitis B virus (HBV) and other viruses, in particular, a use thereof in drugs for HBV Surface antigen inhibitors and HBV DNA production inhibitors. The compound has a significant activity for inhibiting the hepatitis B surface antigen and hepatitis B DNA, and it is possible to significantly improve the probability of curing hepatitis B by administration of same in combination with nucleoside drugs or other drugs in the future, and same has good clinical application prospects.

Inventors:
CHEN LI (CN)
ZHAI PEIBIN (CN)
SHAO QING (CN)
WU JIN (CN)
JIANG TAO (CN)
LI XIAOWEN (CN)
Application Number:
PCT/CN2017/094946
Publication Date:
February 01, 2018
Filing Date:
July 28, 2017
Export Citation:
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Assignee:
GINKGO PHARMA CO LTD (CN)
International Classes:
C07D455/06; A61K31/4375; A61K31/5365; A61K31/542; A61P31/20; C07D471/04; C07D491/048; C07D491/056; C07D498/04; C07D513/04
Domestic Patent References:
WO2015113990A12015-08-06
WO2016071215A12016-05-12
WO2017017042A12017-02-02
Foreign References:
CN106810548A2017-06-09
Other References:
See also references of EP 3492467A4
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT & TRADEMARK AGENCY LTD. (CN)
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