Title:
KAPPA OPIOID AGONISTS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/210436
Kind Code:
A3
Abstract:
Provided are compounds of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds of Formula I described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.
Inventors:
ANAND NEEL K (US)
DUARTE FRANCO J (US)
ZHANG WEN (US)
REN ZHONGXU (US)
DUARTE FRANCO J (US)
ZHANG WEN (US)
REN ZHONGXU (US)
Application Number:
PCT/US2014/044535
Publication Date:
March 26, 2015
Filing Date:
June 27, 2014
Export Citation:
Assignee:
NEKTAR THERAPEUTICS (US)
International Classes:
C07D333/48; A61K31/16; A61K31/165; A61K31/17; A61K31/18; A61K31/381; A61K31/40; A61K31/44; A61K31/4402; A61K31/4965; C07C233/07; C07C241/04; C07C307/10; C07C311/24; C07D207/12
Domestic Patent References:
| WO2008011551A1 | 2008-01-24 | |||
| WO2000014065A1 | 2000-03-16 | |||
| WO1996006078A1 | 1996-02-29 | |||
| WO1994006784A1 | 1994-03-31 |
Foreign References:
| US6057357A | 2000-05-02 | |||
| US20060178426A1 | 2006-08-10 | |||
| EP0254545A2 | 1988-01-27 | |||
| US5232978A | 1993-08-03 | |||
| JPH1112250A | 1999-01-19 |
Other References:
CHANG A-C ET AL: "KAPPA OPIOID RECEPTOR SELECTIVE AFFINITY LABELS: ELECTROPHILIC BENZENEACETAMIDES AS KAPPA-SELECTIVE OPIOID ANTAGONISTS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 37, no. 26, 1 January 1994 (1994-01-01), pages 4490 - 4498, XP001146804, ISSN: 0022-2623, DOI: 10.1021/JM00052A008
MCATEE J J ET AL: "Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 18, no. 13, 1 July 2008 (2008-07-01), pages 3716 - 3719, XP022716282, ISSN: 0960-894X, [retrieved on 20080520], DOI: 10.1016/J.BMCL.2008.05.058
KUMAR V ET AL: "Synthesis and evaluation of novel peripherally restricted kappa-opioid receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 15, no. 4, 15 February 2005 (2005-02-15), pages 1091 - 1095, XP027801841, ISSN: 0960-894X, [retrieved on 20050215]
KUMAR V ET AL: "Amino acid conjugates as kappa opioid receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 15, no. 5, 1 March 2005 (2005-03-01), pages 1279 - 1282, XP027801948, ISSN: 0960-894X, [retrieved on 20050301]
YE TANG ET AL: "A [kappa] Opioid Pharmacophore Becomes a Spinally Selective [kappa]-[delta] Agonist When Modified with a Basic Extender Arm", ACS MEDICINAL CHEMISTRY LETTERS, vol. 2, no. 1, 13 January 2011 (2011-01-13), pages 7 - 10, XP055148946, ISSN: 1948-5875, DOI: 10.1021/ml1001294
BARLOW J J ET AL: "Structure activity studies related to 2-(3,4-dichlorophenyl)-N- methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective.kappa.-opioid agonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 34, no. 11, 1 November 1991 (1991-11-01), pages 3149 - 3158, XP002279326, ISSN: 0022-2623, DOI: 10.1021/JM00115A001
MCATEE J J ET AL: "Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 18, no. 13, 1 July 2008 (2008-07-01), pages 3716 - 3719, XP022716282, ISSN: 0960-894X, [retrieved on 20080520], DOI: 10.1016/J.BMCL.2008.05.058
KUMAR V ET AL: "Synthesis and evaluation of novel peripherally restricted kappa-opioid receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 15, no. 4, 15 February 2005 (2005-02-15), pages 1091 - 1095, XP027801841, ISSN: 0960-894X, [retrieved on 20050215]
KUMAR V ET AL: "Amino acid conjugates as kappa opioid receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 15, no. 5, 1 March 2005 (2005-03-01), pages 1279 - 1282, XP027801948, ISSN: 0960-894X, [retrieved on 20050301]
YE TANG ET AL: "A [kappa] Opioid Pharmacophore Becomes a Spinally Selective [kappa]-[delta] Agonist When Modified with a Basic Extender Arm", ACS MEDICINAL CHEMISTRY LETTERS, vol. 2, no. 1, 13 January 2011 (2011-01-13), pages 7 - 10, XP055148946, ISSN: 1948-5875, DOI: 10.1021/ml1001294
BARLOW J J ET AL: "Structure activity studies related to 2-(3,4-dichlorophenyl)-N- methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective.kappa.-opioid agonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 34, no. 11, 1 November 1991 (1991-11-01), pages 3149 - 3158, XP002279326, ISSN: 0022-2623, DOI: 10.1021/JM00115A001
Attorney, Agent or Firm:
WILSON, Mark, A. (SouthSuite 10, San Francisco CA, US)
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