Title:
KETOLIDE ANTIBACTERIALS
Document Type and Number:
WIPO Patent Application WO2002032918
Kind Code:
A3
Abstract:
The present invention includes compounds of the formula wherein: X is hydrogen or halide; R<2> is hydrogen, acyl, or a hydroxy protecting group; R<6> is hydrogen, hydroxyl, or -OR wherein R is a substituted or unsubstituted moiety selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl; R<13> is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of methyl; C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl;and, R is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl;and the pharmaceutically acceptable salts, esters and pro-drug forms thereof. These compounds possess anti-infective activity and are useful for the treatment of bacterial and protozoal infections.
Inventors:
HLASTA DENNIS
HENNINGER TODD C
GRANT EUGENE B
KHOSLA CHAITIN
CHU DANIEL T W
ASHLEY GARY
HENNINGER TODD C
GRANT EUGENE B
KHOSLA CHAITIN
CHU DANIEL T W
ASHLEY GARY
Application Number:
PCT/US2001/032119
Publication Date:
January 03, 2003
Filing Date:
October 12, 2001
Export Citation:
Assignee:
ORTHO MCNEIL PHARM INC (US)
International Classes:
A61K31/7048; A61P31/04; C07H17/08; (IPC1-7): C07H17/08; A61K31/7048; A61P31/04
Domestic Patent References:
| WO1999035157A1 | 1999-07-15 | |||
| WO2000063224A2 | 2000-10-26 | |||
| WO2000062783A2 | 2000-10-26 |
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