Title:
KETOREDUCTASE POLYPEPTIDES AND POLYNUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO/2021/061915
Kind Code:
A3
Abstract:
The present invention provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme, as well as polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a chiral alcohol. The present invention further provides methods of using the engineered enzymes.
Inventors:
LIANG JACK (US)
SUBRAMANIAN NANDHITHA (US)
CHING CHARLENE (US)
HOMAN DAVID (US)
WHALEN KATIE (US)
JONES MATTHEW (US)
SUBRAMANIAN NANDHITHA (US)
CHING CHARLENE (US)
HOMAN DAVID (US)
WHALEN KATIE (US)
JONES MATTHEW (US)
Application Number:
PCT/US2020/052396
Publication Date:
May 06, 2021
Filing Date:
September 24, 2020
Export Citation:
Assignee:
CODEXIS INC (US)
International Classes:
C07K14/00; C12N9/02; C12N15/53; C12P7/00; C12P13/00; C12P21/00; C12Q1/26
Domestic Patent References:
| WO2010025238A2 | 2010-03-04 |
Foreign References:
| US8426178B2 | 2013-04-23 | |||
| US20130177962A1 | 2013-07-11 | |||
| US20200095619A1 | 2020-03-26 |
Attorney, Agent or Firm:
NEELY WILLIS, Melanie et al. (US)
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