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Title:
L-NUCLEIC ACID DERIVATIVES AND PROCESSES FOR THE SYNTHESIS THEREOF
Document Type and Number:
WIPO Patent Application WO/2002/044194
Kind Code:
A1
Abstract:
A novel process for preparing 2,2'-anhydro-1-(ß-L- arabinofuranosyl)thymine which is novel and a useful intermediate; a novel process for preparing L-thymidine from 2,2'-anhydro-1-(ß-L-arabinofuranosyl)thymine; and a novel process for preparing an L-2'-deoxyribose derivative useful as an intermediate through an L-2,2'-anhydro-5,6-dihydrocyclo- uridine derivative. These processes enable the synthesis of various L-nucleic acid derivatives which were difficult of synthesis.

Inventors:
IIZUKA HAJIME (JP)
TOGASHI KAZUHIKO (JP)
SUZUKI TSUNEJI (JP)
Application Number:
PCT/JP2001/010437
Publication Date:
June 06, 2002
Filing Date:
November 29, 2001
Export Citation:
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Assignee:
MITSUI CHEMICALS INC (JP)
IIZUKA HAJIME (JP)
TOGASHI KAZUHIKO (JP)
SUZUKI TSUNEJI (JP)
International Classes:
C07H3/08; A61K31/7028; C07D498/04; C07D498/14; C07H9/06; C07H19/06; C07H19/073; (IPC1-7): C07H19/073; C07D498/04; C07D498/14; C07H3/02; C07H13/08; C07H15/04
Domestic Patent References:
WO2000009531A22000-02-24
WO1996013512A21996-05-09
Other References:
A. HOLY ET AL.: "Nucleic acid components and their analogues. CLIII. Preparation of 2'-deoxy-L- ribonucleosides of the pyrimidine series", COLLECTION CZECHOSLOV. CHEM. COMMUN., vol. 37, 1972, pages 4072 - 4087, XP002909055
HIROAKI SAWAI ET AL.: "Facile synthesis of 5-substituted arabinofuranosyluracil derivatives", CHEMISTRY LETTERS, 1994, pages 605 - 606, XP002909056
F. CAMARA ET AL.: "Synthesis of L-analogues of 1-(2'-3'dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine", PHARM. PHARMACOL. COMMUN., vol. 5, 1999, pages 225 - 231, XP002909057
VINKO SKARIC ET AL.: "Syntheses of beta-D-arabinofurano(1',2':4,5)oca(thia)zolidines", J. CHEM. SOC., PERKIN TRANS. I, 1985, pages 779 - 783, XP002909058
CHEMICAL ABSTRACTS, vol. 64, 1966, Columbus, Ohio, US; abstract no. 15963B, JOHN F. CODINGTON ET AL. XP002909059
MARC M. GREENBERG ET AL.: "DNA damage induced via 5,6-dihydro-thymid-5-yl in single-stranded oligonucleotides", J. AM. CHEM. SOC., vol. 119, no. 8, 1997, pages 1828 - 1839, XP002909060
MICHAEL E. JUNG ET AL.: "A de novo synthesis of ethyl 2-deoxy-L-ribosides", TETRAHEDRON LETTERS, vol. 39, 1998, pages 4615 - 4618, XP004130876
See also references of EP 1348712A4
Attorney, Agent or Firm:
Kaneda, Nobuyuki (16th Kowa Bldg. 9-20 Akasaka 1-chome Minato-ku, Tokyo, JP)
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