L-PROLINE COMPOUND OF SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITOR, AND MONOHYDRATE AND CRYSTAL OF L-PROLINE COMPOUND

Title:

L-PROLINE COMPOUND OF SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITOR, AND MONOHYDRATE AND CRYSTAL OF L-PROLINE COMPOUND

Document Type and Number:

WIPO Patent Application WO/2016/050134

Kind Code:

A1

Abstract:

Provided are an L-proline compound of a sodium-glucose cotransporter 2 inhibitor, and a monohydrate and a crystal of the L-proline compound. Specifically, provided are 1,6-dehydrated-1-C{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)methyl]phenyl}-5-C-(hydroxymethyl)-β-L-idopyranose L-proline (a compound of formula (I)), a monohydrate and an A-type crystal thereof and a preparation method therefor. The obtained A-type crystal of the compound of formula (I) has good chemical stability and crystal stability, and a crystallization solvent used has low toxicity and low residue, so the A-type crystal can be better used in clinical treatment.

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Inventors:

SUN PIAOYANG (CN)
WU GUAILI (CN)
GUO CHANGSHAN (CN)
LU YUN (CN)
WU YUXIA (CN)
SHEN LINGJIA (CN)

Application Number:

PCT/CN2015/089128

Publication Date:

April 07, 2016

Filing Date:

September 08, 2015

Export Citation:

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Assignee:

JIANGSU HENGRUI MEDICINE CO (CN)

International Classes:

C07H9/04; A61K31/7048; A61K47/12; A61K47/26; A61P3/10; C07D207/16; C07D493/08; C07H1/00

Foreign References:

CN104017031A	2014-09-03
CN104031098A	2014-09-10
CN102149717A	2011-08-10
CN102372722A	2012-03-14

Other References: