Title:
LOW-DOSE IL-1 beta -INDUCED PHOTORECEPTOR CELL RESCUE WITHOUT RETINAL DYSPLASIA
Document Type and Number:
WIPO Patent Application WO2000068267
Kind Code:
A9
Abstract:
The present invention relates to the discovery that low levels of IL-1 beta , administered at 50 mu g/ml or less, preferably 10 g DOLLAR (m)g/ml or less, can still induce rescue of neuronal cells such as photoreceptor cells, while minimizing IL-1 beta 's destructive sequelae, such as retinal dysplasia and intraocular inflammation.
Inventors:
KLASSEN HENRY (US)
WHITELEY SIMON J (US)
YOUNG MICHAEL J (US)
WHITELEY SIMON J (US)
YOUNG MICHAEL J (US)
Application Number:
PCT/US2000/012565
Publication Date:
June 14, 2001
Filing Date:
May 08, 2000
Export Citation:
Assignee:
SCHEPENS EYE RES INST (US)
KLASSEN HENRY (US)
WHITELEY SIMON J (US)
YOUNG MICHAEL J (US)
KLASSEN HENRY (US)
WHITELEY SIMON J (US)
YOUNG MICHAEL J (US)
International Classes:
A61K38/00; A61K38/20; A61P25/28; A61P27/02; C07K14/545; A61K38/12; (IPC1-7): C07K14/545; A61K38/20
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