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Title:
LACTIC ACID BACTERIA THAT PRODUCE NICOTINAMIDE RIBOSIDE, AND LACTIC ACID BACTERIA THAT PRODUCE NICOTINAMIDE MONONUCLEOTIDE AND NICOTINAMIDE RIBOSIDE
Document Type and Number:
WIPO Patent Application WO/2021/070829
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide microorganisms which efficiently produce nicotinamide riboside, and microorganisms which can efficiently produce both nicotinamide mononucleotide and nicotinamide riboside. Nicotinamide mononucleotide and nicotinamide riboside can be produced by culturing lactic acid bacteria belonging to the genus Fructobacillus.

Inventors:
YOSHIDA NOBUYUKI (JP)
NISHIKAWA KOUJI (JP)
IDOGAKI HIDEAKI (JP)
Application Number:
PCT/JP2020/037902
Publication Date:
April 15, 2021
Filing Date:
October 06, 2020
Export Citation:
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Assignee:
UNIV SHIZUOKA NAT UNIV CORP (JP)
OSAKA SODA CO LTD (JP)
International Classes:
A23L33/10; A61P43/00; A61K8/00; A61K8/49; A61K31/706; C12N1/20; C12P19/30
Domestic Patent References:
WO2015069860A12015-05-14
WO2017200050A12017-11-23
WO2017083858A22017-05-18
Foreign References:
JP2019501638A2019-01-24
JP2019513385A2019-05-30
Other References:
KODAMA, REIJIRO: "Studies on the Nutrition of Lactic Acid Bacteria. Part I. On the Nutrition of a Strain", NIPPON NOGEI KAGAKU KAISHI = JOURNAL OF THE AGRICULTURAL CHEMICAL SOCIETY OF JAPAN, vol. 30, no. 4, 30 November 1955 (1955-11-30), JP , pages 219 - 224, XP009534238, ISSN: 0002-1407, DOI: 10.1271/nogeikagaku1924.30.4_219
JAFFAR, NORZAWANI ET AL.: "Mature Biofilm Degradation by Potential Probiotics: Aggregatibacter actinomycetemcomitans versus Lactobacillus spp", PLOS ONE, vol. 11, no. 7, 20 July 2016 (2016-07-20), pages e0159466, XP055817965
OHTSU, EIJI ET AL.: "Pathways of nicotinamide adenine dinucleotide biosynthesis in nicotinic acid or nicotinamide requiring microorganisms", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 29, no. 5, 1967, pages 635 - 641, XP024778510, DOI: 10.1016/0006-291X(67)90263-X
KODAMA, REIJIRO: "Studies on the Nutrition of Lactic Acid Bacteria. Part IV. Lactobacillus fructosus nov. sp., A New Species of Lactic Acid Bacteria", NIPPON NOGEI KAGAKU KAISHI = JOURNAL OF THE AGRICULTURAL CHEMICAL SOCIETY OF JAPAN, vol. 30, no. 11, 30 November 1955 (1955-11-30), JP , pages 705 - 708, XP009534239, ISSN: 0002-1407, DOI: 10.1271/nogeikagaku1924.30.11_705
ASANUMA, KAI; OIKAWA, YOU, TANAKA, NAOTO; KAJIKAWA, AKINOBU; ENDO, AKIHITO; SATOH, EIICHI; OKADA, SANAE: "2A09a05: Characteristics and Sugar Metabolism in the Genus Fructobacillus", ANNUAL MEETING OF THE JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2014 (JSBBA 2014), vol. 2014, 30 November 2013 (2013-11-30), pages 320, XP009534289
IMAI, S.GUARENTE, L., TRENDS CELL BIOL., vol. 24, 2014, pages 464 - 471
GUARENTE, L., GENES DEV, vol. 27, 2013, pages 2072 - 2085
Attorney, Agent or Firm:
TANAKA, Junya et al. (JP)
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