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Title:
LACTOBACILLUS FERMENTUM CAPABLE OF PREVENTING AND/OR TREATING PERIODONTITIS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/134710
Kind Code:
A1
Abstract:
A strain of Lactobacillus fermentum CCFM1139 and an application thereof are provided. The Lactobacillus fermentum has a preservation number of GDMCC No: 61116, and has the effect of relieving periodontitis. Same can inhibit the formation of a mixed biofilm of Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum, enabling the amount of biofilm to decrease by 52.45%, enabling the content of TNF-α in a periodontitis cell model to decrease from 131.37 pg/mL to 83.31 pg/mL, and the content of IL-8 to decrease from 147.70 pg/mL to 121.12 pg/mL, enabling the colonization of Porphyromonas gingivalis and Fusobacterium nucleatum in the oral cavity to decrease by 1-2 orders of magnitude, and and enabling the amount of alveolar bone resorption to decrease from 1838.0 μm to 805.7 μm.

Inventors:
CHEN WEI (CN)
ZHANG QIUXIANG (CN)
XU WANQING (CN)
LU WENWEI (CN)
ZHANG HAO (CN)
ZHAO JIANXIN (CN)
Application Number:
PCT/CN2021/121338
Publication Date:
June 30, 2022
Filing Date:
September 28, 2021
Export Citation:
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Assignee:
UNIV JIANGNAN (CN)
International Classes:
C12N1/20; A23C9/123; A23G4/12; A23L33/135; A61K8/99; A61K35/747; A61P1/02; A61P31/04; A61Q11/00; C12R1/225
Foreign References:
CN112608864A2021-04-06
CN111642746A2020-09-11
CN102226157A2011-10-26
CN111904985A2020-11-10
JP2012044951A2012-03-08
Other References:
CHEN LING-JU, TSAI HSIU-TING, CHEN WEI-JEN, HSIEH CHU-YANG, WANG PI-CHIEH, CHEN CHUNG-SHIH, WANG LINA, YANG CHI-CHIANG: "In vitro antagonistic growth effects of Lactobacillus fermentum and Lactobacillus salivarius and their fermentative broth on periodontal pathogens", BRAZILIAN JOURNAL OF MICROBIOLOGY, SOCIEDADE BRASILEIRA DE MICROBIOLOGIA,BRAZILIAN SOCIETY FOR MICROBIOLOGY, BR, vol. 43, no. 4, 1 January 2012 (2012-01-01), BR , pages 1376 - 1384, XP055944566, ISSN: 1517-8382, DOI: 10.1590/S1517-83822012000400019
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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