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Title:
LACTOBACILLUS PARACASEI CAPABLE OF REGULATING SYMPTOMS OF INTESTINAL IMMUNE DISORDERS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/168808
Kind Code:
A1
Abstract:
Provided is a novel Lactobacillus paracasei VHProbi F22 strain, having a preservation number of CCTCC No: M2019941. Further provided is a use of Lactobacillus paracasei in regulating intestinal immune disorders, removing DPPH free radicals, and degrading cholesterol. The Lactobacillus paracasei VHProbi F22 has strong tolerance to artificial intestinal and gastric juice, does not generate hemolysin, does not dissolve blood cells, is sensitive to common antibiotics such as erythromycin and tetracycline, has good biological safety, and can tolerate higher salinity. The strain is high in oxidation resistance and can effectively degrade the cholesterol. In addition, the strain has a cell surface hydrophobicity of 70.61%, and has a certain adhesion capability. The Lactobacillus paracasei VHProbi F22 can effectively relieve symptoms of the intestinal immune disorders.

Inventors:
DUAN ZHI (CN)
CUI HONGCHANG (CN)
WU SONGJIE (CN)
ZHANG JINGYAN (CN)
ZHANG LUXIA (CN)
Application Number:
PCT/CN2022/088946
Publication Date:
September 14, 2023
Filing Date:
April 25, 2022
Export Citation:
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Assignee:
QINGDAO VLAND BIOTECH INC (CN)
QINGDAO VLAND BIOTECH GROUP CO LTD (CN)
International Classes:
C12N1/20; A23L33/135
Foreign References:
CN105368738A2016-03-02
CN106819106A2017-06-13
CN105400727A2016-03-16
CN107227280A2017-10-03
CN104531567A2015-04-22
CN108148784A2018-06-12
Other References:
SZLISZKA EWELINA, CZUBA ZENON P., DOMINO MACIEJ, MAZUR BOGDAN, ZYDOWICZ GRZEGORZ, KROL WOJCIECH: "Ethanolic Extract of Propolis (EEP) Enhances the Apoptosis- Inducing Potential of TRAIL in Cancer Cells", MOLECULES, vol. 14, no. 2, 13 February 2009 (2009-02-13), pages 738 - 754, XP093090064, DOI: 10.3390/molecules
Attorney, Agent or Firm:
BEIJING JUNHUI INTELLECTUAL PROPERTY AGENT OFFICE (ORDINARY PARTNERSHIP) (CN)
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