Title:
LEWIS-ASSOCIATED COMPOUND, PROCESS FOR PRODUCING THE SAME, AND ANTI-INFLAMMATORY
Document Type and Number:
WIPO Patent Application WO/1994/020514
Kind Code:
A1
Abstract:
A Lewis-associated compound, represented by general formula (I), a process for producing the same, and an anti-inflammatory, wherein R1 and R3 represent each hydrogen, SO3H or CH2COOH; R2 represents hydrogen, SO3H, CH2COOH or N-acetyl-neutraminic acid residue; R4 represents hydrogen; R5 represents O-lower alkyl, O-lower alkenyl, O-ceramide residue, O-mannose residue, O-galactose residue or O-lactose residue; R6 represents acetylamine; and R7 and R8 represent each hydrogen.
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Inventors:
NUMATA MASAAKI (JP)
NUNOMURA SHIGEKI (JP)
FUJITA SHUJI (JP)
IIDA MASAMI (JP)
ENDO AKIRA (JP)
ISHII TAKAYUKI (JP)
OGAWA TOMOYA (JP)
SUGIMOTO MAMORU (JP)
OSAWA RYOICHI (JP)
FUJITA MASAMICHI (JP)
NUNOMURA SHIGEKI (JP)
FUJITA SHUJI (JP)
IIDA MASAMI (JP)
ENDO AKIRA (JP)
ISHII TAKAYUKI (JP)
OGAWA TOMOYA (JP)
SUGIMOTO MAMORU (JP)
OSAWA RYOICHI (JP)
FUJITA MASAMICHI (JP)
Application Number:
PCT/JP1994/000352
Publication Date:
September 15, 1994
Filing Date:
March 04, 1994
Export Citation:
Assignee:
KANTO ISHI PHARMA CO LTD (JP)
NUMATA MASAAKI (JP)
NUNOMURA SHIGEKI (JP)
FUJITA SHUJI (JP)
IIDA MASAMI (JP)
ENDO AKIRA (JP)
ISHII TAKAYUKI (JP)
OGAWA TOMOYA (JP)
SUGIMOTO MAMORU (JP)
OSAWA RYOICHI (JP)
FUJITA MASAMICHI (JP)
NUMATA MASAAKI (JP)
NUNOMURA SHIGEKI (JP)
FUJITA SHUJI (JP)
IIDA MASAMI (JP)
ENDO AKIRA (JP)
ISHII TAKAYUKI (JP)
OGAWA TOMOYA (JP)
SUGIMOTO MAMORU (JP)
OSAWA RYOICHI (JP)
FUJITA MASAMICHI (JP)
International Classes:
C07H3/06; C07H13/04; C07H15/04; C07H15/10; (IPC1-7): C07H15/10; C07H15/18; C07H13/06; C07H3/06; C08B37/00; A61K37/20
Domestic Patent References:
| WO1993024505A1 | 1993-12-09 |
Foreign References:
| JPH02174696A | 1990-07-06 |
Other References:
Journal of American Chemical Society; Vol. 114 (No. 13), p. 5449-5451 (1992), G.E. BALL et al., "Synthesis and Structural Using 2-D NMR of Sialyl Lewis X and Lewis X Origosaccharides".
Journal of American Chemical Society; Vol. 112 (No. 9), p. 3693-3695 (1990), K.C. NICOLAU et al., "Total Synthesis of Tumor-Associated Lex Family of Glycosphingolipides".
Carbohydrate Research; Vol. 183 (No. 1), p. 71-82 (1988), M. NILSSON & T. NORBERG, "Synthesis of a Dimeric Lewis-X Hexa Saccharide Derivative Corresponding to a Tumor-Associated Glycolipid".
See also references of EP 0687684A4
Journal of American Chemical Society; Vol. 112 (No. 9), p. 3693-3695 (1990), K.C. NICOLAU et al., "Total Synthesis of Tumor-Associated Lex Family of Glycosphingolipides".
Carbohydrate Research; Vol. 183 (No. 1), p. 71-82 (1988), M. NILSSON & T. NORBERG, "Synthesis of a Dimeric Lewis-X Hexa Saccharide Derivative Corresponding to a Tumor-Associated Glycolipid".
See also references of EP 0687684A4
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