Title:
LIGANDS OF ADENINE NUCLEOTIDE TRANSLOCASE (ANT) AND COMPOSITIONS AND METHODS RELATED THERETO
Document Type and Number:
WIPO Patent Application WO2004058683
Kind Code:
A3
Abstract:
Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
Inventors:
GHOSH SOUMITRA S (US)
PEI YAZHONG (US)
TANG XIAO-QING (US)
PEI YAZHONG (US)
TANG XIAO-QING (US)
Application Number:
PCT/US2003/041213
Publication Date:
September 30, 2004
Filing Date:
December 19, 2003
Export Citation:
Assignee:
MITOKOR INC (US)
GHOSH SOUMITRA S (US)
PEI YAZHONG (US)
TANG XIAO-QING (US)
GHOSH SOUMITRA S (US)
PEI YAZHONG (US)
TANG XIAO-QING (US)
International Classes:
C07C229/38; C07C233/81; C07C251/24; C07C275/42; C07C311/08; C07C335/16; (IPC1-7): C07C275/42; A61K31/603; A61K31/606; C07C229/38; C07C251/24; C07C311/08
Domestic Patent References:
| WO2003080564A1 | 2003-10-02 |
Foreign References:
| US6262113B1 | 2001-07-17 |
Other References:
TAIT B D ET AL: "CATECHOL BASED INHIBITORS OF 15-LIPOXYGENASE", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 1, 1996, pages 93 - 96, XP009030975, ISSN: 0960-894X
TUNA F ET AL: "A SYNTHETIC APPROACH TOWARDS HOMOTRINUCLEAR COMPLEXES: DESIGN OF MN(II), NI(II), CU(II), AND ZN(II) COMPLEXES USING A NEW UNSYMMETRICAL TETRADENTATE LIGAND", REVUE ROUMAINE DE CHIMIE, BUKAREST, RO, vol. 42, no. 7, 1997, pages 579 - 585, XP009030976
SYAMAL A ET AL: "SYNTHESIS AND CHARACTERIZATION OF NEW POLYMER SUPPORTED CHELATING RESINS", JOURNAL OF POLYMER MATERIALS, CALCUTTA, IN, no. 3, 1989, pages 175 - 179, XP009030971
TUNA F ET AL: "A SYNTHETIC APPROACH TOWARDS HOMOTRINUCLEAR COMPLEXES: DESIGN OF MN(II), NI(II), CU(II), AND ZN(II) COMPLEXES USING A NEW UNSYMMETRICAL TETRADENTATE LIGAND", REVUE ROUMAINE DE CHIMIE, BUKAREST, RO, vol. 42, no. 7, 1997, pages 579 - 585, XP009030976
SYAMAL A ET AL: "SYNTHESIS AND CHARACTERIZATION OF NEW POLYMER SUPPORTED CHELATING RESINS", JOURNAL OF POLYMER MATERIALS, CALCUTTA, IN, no. 3, 1989, pages 175 - 179, XP009030971
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