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Title:
LIGNAN GLYCOSIDE COMPOUND FROM BARK OF ALBIZIA JULIBRISSIN FOR PROMOTING ENDOTHELIAL CELL PROLIFERATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/063078
Kind Code:
A1
Abstract:
Provided is use of Icarisid E5 in promoting endothelial cell proliferation and migration and promoting angiogenesis. It is proved by experiments that 24 hours after administration of said compound in 40 μM, HUVEC cell activity can increase to 133.65% of the activity of the control. The compound can significantly promote cell migration, and promote wound healing in vivo experiments. The prepared monomer compound Icarisid E5 can significantly promote cell proliferation viability and promote the HUVEC cell migration and self-replication, and can be used to transfer exogenous angiogenesis-inducing factors into tissues, promote angiogenesis, and enhance the cell proliferation ability.

Inventors:
QIU LIYING (CN)
SHI XUELIN (CN)
HOU BAO (CN)
CAI WEIWEI (CN)
NI LULU (CN)
ZHOU YUETAO (CN)
Application Number:
PCT/CN2020/102569
Publication Date:
April 08, 2021
Filing Date:
July 17, 2020
Export Citation:
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Assignee:
UNIV JIANGNAN (CN)
International Classes:
A61K31/7034; A23L33/105; A23L33/125; A61P9/00; A61P17/02; A61P35/00
Domestic Patent References:
WO2011089161A12011-07-28
Foreign References:
CN110638822A2020-01-03
CN110563781A2019-12-13
CN101167787A2008-04-30
Other References:
SHI, LI, CAI, LIU, AI, SUN, HOU, NI, QIU: "Chemical Constituents from Albiziae Cortex and Their Ability to Ameliorate Steatosis and Promote Proliferation and Anti-oxidation In Vitro", MOLECULES, vol. 24, no. 22, pages 4041, XP055796834, DOI: 10.3390/molecules24224041
WEI, DONGHONG: "Studies on the Active Constituents of Cortex Albizziae", MEDICINE & PUBLIC HEALTH, CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES FULL-TEXT DATABASES, no. 04, 15 December 2004 (2004-12-15), pages 1 - 78, XP009527040
REN GANG, LUO ZHANG-PING, LI WEN-YAN, ZHU GEN-HUA, SHAO FENG, HUANG HUI-LIAN, LIU RONG-HUA: "Isolation and Anti-PMN Respiratory Burst Activity of Phenylpropanoids Compounds from Dendropanax chevalieri", CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE, vol. 19, no. 14, 31 July 2013 (2013-07-31), pages 80 - 83, XP009527041, ISSN: 1005-9903
LEE DAE-YOUNG, LEE DO-GYEONG, CHO JIN-GYEONG, BANG MYUN-HO, LYU HA-NA, LEE YOUN-HYUNG, KIM SE-YOUNG, BAEK NAM-IN: "Lignans from the fruits of the red pepper (Capsicum annuum L.) and their antioxidant effects", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 32, no. 10, 1 October 2009 (2009-10-01), KR, pages 1345 - 1349, XP055796836, ISSN: 0253-6269, DOI: 10.1007/s12272-009-2001-8
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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