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Title:
LINCOMYCIN DERIVATIVES AND ANTIBACTERIAL AGENTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2008/146917
Kind Code:
A1
Abstract:
Compounds represented by the general formula (1) [wherein A is aryl; R1 is N-(optionally substituted C1-6 alkyl)-N-(optionally substituted C1-6 alkyl)amino-C1-6 alkyl; R2 is hydrogen or optionally substituted C1-6 alkyl; R3 is optionally substituted C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; m is 1 to 3; n is 0; and p is 0 to 2], or pharmacologically acceptable salts or solvates thereof. These compounds are novel lincomycin derivatives having potent activity against drug-resistant pneumococcus which is a recent problem in the treatment of infectious disease. The compounds can be used as antibacterial agent and are useful in the prevention or treatment of bacterial infectious disease.

Inventors:
WAKIYAMA YOSHINARI (JP)
KUMURA KOU (JP)
MASAKI SATOMI (JP)
UEDA KAZUTAKA (JP)
SATO YASUO (JP)
KIKUCHI CHIKA (JP)
UMEMURA EIJIROU (JP)
HIRAI YOKO (JP)
KONDO HIROSHI (JP)
Application Number:
PCT/JP2008/060042
Publication Date:
December 04, 2008
Filing Date:
May 30, 2008
Export Citation:
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Assignee:
MEIJI SEIKA KAISHA (JP)
WAKIYAMA YOSHINARI (JP)
KUMURA KOU (JP)
MASAKI SATOMI (JP)
UEDA KAZUTAKA (JP)
SATO YASUO (JP)
KIKUCHI CHIKA (JP)
UMEMURA EIJIROU (JP)
HIRAI YOKO (JP)
KONDO HIROSHI (JP)
International Classes:
C07H15/16; A61K31/7052; A61K31/7056; A61K31/706; A61P11/00; A61P31/04
Domestic Patent References:
WO2005012320A22005-02-10
WO2005007665A22005-01-27
WO2006055070A22006-05-26
WO2007066805A12007-06-14
Foreign References:
JP2006504673A2006-02-09
Other References:
SZTARICSKAI F. ET AL.: "Semisynthetic modification of antibiotic lincomycin", J. ANTIBIOTICS, vol. 49, no. 9, 1996, pages 941 - 943, XP009044907
BIRKENMEYER R.D. ET AL.: "Synthesis and antimicrobial activity of clindamycin analogues: Prilimycin, a potent antibacterial agent", J. MED. CHEM., vol. 27, no. 2, 1984, pages 216 - 223, XP002174848
See also references of EP 2151447A4
Attorney, Agent or Firm:
YOSHITAKE, Kenji et al. (Room 323 Fuji Bldg.,2-3, Marunouchi 3-chom, Chiyoda-ku Tokyo 05, JP)
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