Title:
LINCOSAMIDE ANTIBIOTICS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/032936
Kind Code:
A8
Abstract:
Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.
Inventors:
MYERS ANDREW (US)
MITCHELTREE MATTHEW (US)
SILVESTRE KATHERINE (US)
MITCHELTREE MATTHEW (US)
SILVESTRE KATHERINE (US)
Application Number:
PCT/US2018/046167
Publication Date:
April 04, 2019
Filing Date:
August 10, 2018
Export Citation:
Assignee:
HARVARD COLLEGE (US)
International Classes:
A61K31/409; A61K31/7042; A61K31/7056; C07D309/02; C07D498/02; C07H15/16
Attorney, Agent or Firm:
DUFFEY, Matthew, O. (US)
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