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Title:
LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2022/152109
Kind Code:
A2
Abstract:
Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

Inventors:
YING BO (CN)
WANG XIULIAN (CN)
Application Number:
PCT/CN2022/071251
Publication Date:
July 21, 2022
Filing Date:
January 11, 2022
Export Citation:
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Assignee:
SUZHOU ABOGEN BIOSCIENCES CO LTD (CN)
International Classes:
C07C217/08; A61K9/127; A61K9/51; A61K31/7105; A61K47/18; C07C211/58; C07C219/06; C07C219/14; C07C229/14; C07C229/24; C07C229/30; C07C233/36; C07C237/06; C07C271/12; C07C271/20; C07D211/58; C07F9/22; C07F9/24
Domestic Patent References:
WO2012067378A22012-05-24
WO2015199952A12015-12-30
WO2016176330A12016-11-03
WO2015011633A12015-01-29
WO2017112865A12017-06-29
WO2008127688A12008-10-23
WO2008016473A22008-02-07
WO2011015347A12011-02-10
WO2007025008A22007-03-01
WO2001055369A12001-08-02
WO2009075886A12009-06-18
WO2012009644A22012-01-19
WO1999024595A11999-05-20
WO2001055371A12001-08-02
WO2013103659A12013-07-11
WO2012019780A12012-02-16
WO2015002667A12015-01-08
WO2013120497A12013-08-22
WO2013120629A12013-08-22
WO2013120500A12013-08-22
WO2013120627A12013-08-22
WO2013120498A12013-08-22
WO2013120626A12013-08-22
WO2013120499A12013-08-22
WO2013120628A12013-08-22
WO2002098443A22002-12-12
WO2003051401A22003-06-26
WO2008052770A22008-05-08
WO2009127230A12009-10-22
WO2006122828A22006-11-23
WO2008083949A22008-07-17
WO2010088927A12010-08-12
WO2010037539A12010-04-08
WO2004004743A12004-01-15
WO2005016376A12005-02-24
WO2006024518A12006-03-09
WO2007095976A22007-08-30
WO2008014979A22008-02-07
WO2008077592A12008-07-03
WO2009030481A12009-03-12
WO2009095226A22009-08-06
WO2011069586A12011-06-16
WO2011026641A12011-03-10
WO2011144358A12011-11-24
WO2012013326A12012-02-02
WO2012089338A12012-07-05
WO2012113513A12012-08-30
WO2012116811A12012-09-07
WO2012116810A12012-09-07
WO2013113502A12013-08-08
WO2013113501A12013-08-08
WO2013113736A12013-08-08
WO2013143698A12013-10-03
WO2013143699A12013-10-03
WO2013143700A22013-10-03
WO2013174409A12013-11-28
WO2014127917A12014-08-28
WO2015024669A12015-02-26
WO2015024668A22015-02-26
WO2015024667A12015-02-26
WO2015024665A12015-02-26
WO2015024666A12015-02-26
WO2015024664A12015-02-26
WO2015101415A12015-07-09
WO2015101414A22015-07-09
WO2015062738A12015-05-07
WO2015101416A12015-07-09
Foreign References:
US8519110B22013-08-27
US7468275B22008-12-23
US20070048776A12007-03-01
US20110124100A12011-05-26
US6310197B12001-10-30
US6849405B22005-02-01
US7456273B22008-11-25
US7183395B22007-02-27
US20090226470A12009-09-10
US20130177581A12013-07-11
US20090093049A12009-04-09
EP2610341A12013-07-03
EP2610340A12013-07-03
Other References:
SAMBROOK: "Molecular Cloning: A Laboratory Manual", 2001
"Current Protocols in Molecular Biology", 2003
BUNDGARD, H.: "Design of Prodrugs", vol. 21-24, 1985, ELSEVIER, pages: 7 - 9
HIGUCHI, T. ET AL., A.C.S. SYMPOSIUM SERIES, vol. 14
"Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
WELLENSIEK ET AL.: "Genome-wide profiling of human cap-independent translation-enhancing elements", NATURE METHODS, vol. 10, no. 8, August 2013 (2013-08-01), pages 747 - 750, XP055658496, DOI: 10.1038/nmeth.2522
CHAPPELL ET AL., PNAS, vol. 101, no. 26, 29 June 2004 (2004-06-29), pages 9590 - 9594
PANEK ET AL., NUCLEIC ACIDS RESEARCH, vol. 41, 1 September 2013 (2013-09-01), pages 7625 - 7634
"Mol. Biology and Biotechnology: A Comprehensive Desk Reference", 1995
KUBY: "Immunology", 1997
PLIICKTHUNSKERRA, METH. ENZYMOL., vol. 178, 1989, pages 497 - 515
HUSTON ET AL., CELL BIOPHYSICS, vol. 22, 1993, pages 189 - 224
DAY: "Advanced Immunochemistry", 1990
"Physician's Desk Reference", 2014
SABNIS ET AL.: "A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates", MOLECULAR THERAPY, vol. 26, no. 6, 2018, XP055644778, DOI: 10.1016/j.ymthe.2018.03.010
KORE ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 4570 - 4574
CHAPPELL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 9590 - 9594
ZHOU ET AL., PROC. NATL. ACAD. SCI., vol. 102, 2005, pages 6273 - 6278
KEDDE ET AL.: "A Pumilio-induced RNA structure switch in p27-3'UTR controls miR-221 and miR-222 accessibility", NAT CELL BIOL., vol. 12, no. 10, October 2010 (2010-10-01), pages 1014 - 20
A. R. GENNARO: "Remington's The Science and Practice of Pharmacy", 2006, LIPPINCOTT, WILLIAMS & WILKINS
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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