Title:
LIPID PHARMACEUTICAL PREPARATION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/211762
Kind Code:
A1
Abstract:
A lipid pharmaceutical preparation and application thereof. The lipid pharmaceutical preparation comprises local anesthetics and lipid substances. The mass percentage of the local anesthetic in the lipid pharmaceutical preparation is 2%-50%. The local anesthetics are lidocaine, tetracaine, bupivacaine, articaine, cinchocaine, dibucaine, etidocaine, levobupivacaine, mepivacaine, prilocaine, ropivacaine, trimecaine, benzocaine, or procaine. The mass percentage of the lipid substances in the lipid pharmaceutical preparation is 30%-98%. The sum of the mass percentages of the components in the lipid pharmaceutical preparation is 100%. In general analgesic application, the lipid pharmaceutical preparation can produce continuous and safe analgesic effects for 12, 24, 36, 48, or 72 hours, or even longer.
Inventors:
ZHANG JIE (CN)
TANG PEIKE (CN)
TANG PEIKE (CN)
Application Number:
PCT/CN2020/084832
Publication Date:
October 22, 2020
Filing Date:
April 15, 2020
Export Citation:
Assignee:
HUZHOU INNOVATION PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K45/00; A61K9/08; A61K9/107; A61K31/167; A61K31/445; A61K47/24; A61P23/02; A61P29/00
Domestic Patent References:
| WO2003077885A2 | 2003-09-25 |
Foreign References:
| CN101636148A | 2010-01-27 | |||
| CN101027065A | 2007-08-29 | |||
| CN1152873A | 1997-06-25 | |||
| CN108354903A | 2018-08-03 | |||
| CN108379269A | 2018-08-10 | |||
| US4647586A | 1987-03-03 | |||
| CN201910299949A | 2019-04-15 |
Other References:
YUKO IKEDA ET AL.: "Pharmacokinetics of Lidocaine, Bupivacaine, and Levobupivacaine in Plasma and Brain in Awake Rats", ; ANESTHESIOLOGY, vol. 112, 2010, pages 1396 - 1403
See also references of EP 3957328A4
See also references of EP 3957328A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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