Title:
LIPID SECRETION PROMOTING AGENT
Document Type and Number:
WIPO Patent Application WO/2021/261576
Kind Code:
A1
Abstract:
A promoting agent for the secretion of a lipid, which contains diquafosol or a salt thereof as an active ingredient, in which the type of the secretion of the lipid is of a holocrine type. An ophthalmic composition containing diquafosol or a salt thereof as an active ingredient, which is intended to be used for the promotion of the secretion of a lipid, in which the type of the secretion of the lipid is of a holocrine type. An ophthalmic composition containing diquafosol or a salt thereof, which is intended to be used in an in vivo treatment method for promoting the holocrine-type secretion of a lipid from a meibomian gland cell. An ophthalmic composition containing diquafosol or a salt thereof, which is intended to be used in an in vivo treatment method for promoting the secretion of a lipid from a meibomian gland cell, in which the lipid is at least one component selected from the group consisting of a wax ester, a triglyceride, an omega-hydroxy lipid, cholesterol, a cholesterol ester, total cholesterol, a phospholipid, a fatty acid and a fatty alcohol.
Inventors:
ENDO KENICHI (JP)
FUJISAWA KOUSHI (JP)
KAMIMURA ASUKA (JP)
FUJISAWA KOUSHI (JP)
KAMIMURA ASUKA (JP)
Application Number:
PCT/JP2021/024074
Publication Date:
December 30, 2021
Filing Date:
June 25, 2021
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/7084; A61P27/02
Foreign References:
| JP2011527709A | 2011-11-04 |
Other References:
FUKUOKA SHIMA, ARITA REIKO: "Increase in tear film lipid layer thickness after instillation of 3% diquafosol ophthalmic solution in healthy human eyes", OCULAR SURFACE, vol. 15, no. 4, 1 October 2017 (2017-10-01), pages 730 - 735, XP055893665, ISSN: 1542-0124, DOI: 10.1016/j.jtos.2017.03.005
FUKUOKA SHIMA, ARITA REIKO: "Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction: a randomized clinical study", SCIENTIFIC REPORTS, vol. 9, no. 9091, 24 June 2019 (2019-06-24), XP055893668, DOI: 10.1038/s41598-019-45475-7
SIN MAN LAM, LOUIS TONG, SIEW SIAN YONG, BOWEN LI, SHYAM S. CHAURASIA, GUANGHOU SHUI, MARKUS R. WENK: "Meibum Lipid Composition in Asians with Dry Eye Disease", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 6, no. 10, 1 January 2011 (2011-01-01), pages e24339, XP055013727, ISSN: 19326203, DOI: 10.1371/journal.pone.0024339
ENDO KEN-ICHI, SAKAMOTO ASUKA, FUJISAWA KOUSHI: "Diquafosol tetrasodium elicits total cholesterol release from rabbit meibomian gland cells via P2Y2 purinergic receptor signalling", SCIENTIFIC REPORTS, vol. 11, no. 1, 26 March 2021 (2021-03-26), pages 6989, XP055893672, DOI: 10.1038/s41598-021-86433-6
FUKUOKA SHIMA, ARITA REIKO: "Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction: a randomized clinical study", SCIENTIFIC REPORTS, vol. 9, no. 9091, 24 June 2019 (2019-06-24), XP055893668, DOI: 10.1038/s41598-019-45475-7
SIN MAN LAM, LOUIS TONG, SIEW SIAN YONG, BOWEN LI, SHYAM S. CHAURASIA, GUANGHOU SHUI, MARKUS R. WENK: "Meibum Lipid Composition in Asians with Dry Eye Disease", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 6, no. 10, 1 January 2011 (2011-01-01), pages e24339, XP055013727, ISSN: 19326203, DOI: 10.1371/journal.pone.0024339
ENDO KEN-ICHI, SAKAMOTO ASUKA, FUJISAWA KOUSHI: "Diquafosol tetrasodium elicits total cholesterol release from rabbit meibomian gland cells via P2Y2 purinergic receptor signalling", SCIENTIFIC REPORTS, vol. 11, no. 1, 26 March 2021 (2021-03-26), pages 6989, XP055893672, DOI: 10.1038/s41598-021-86433-6
Attorney, Agent or Firm:
FUKAMI PATENT OFFICE, P.C. et al. (JP)
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