Title:
LIVER-TARGETING COMPOUND HAVING THYROID HORMONE RECEPTOR AGONIST CHARACTERISTICS AND PHARMACEUTICAL COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/135335
Kind Code:
A1
Abstract:
The present invention belongs to the field of biomedicine, specifically relates to the field of targeting medicine. More specifically, the present invention relates to a liver-targeting compound having thyroid hormone receptor agonist characteristics and a pharmaceutical composition thereof. The compound is a compound represented by formula (1). The compound can be used for treating and/or preventing diseases caused by thyroid hormone dysregulation, and can also effectively reduce lipids in plasma and liver cells. (I)
Inventors:
CUI KUNYUAN (CN)
WANG SHENGJUN (CN)
DU YANCHUN (CN)
WANG SHENGJUN (CN)
DU YANCHUN (CN)
Application Number:
PCT/CN2020/112941
Publication Date:
July 08, 2021
Filing Date:
September 02, 2020
Export Citation:
Assignee:
KYLONOVA XIAMEN BIOPHARMA CO LTD (CN)
International Classes:
A61K31/7032; C07H15/04; A61P1/16; C07H1/00
Foreign References:
| CN111116684A | 2020-05-08 | |||
| CN109331185A | 2019-02-15 | |||
| CN107929273A | 2018-04-20 |
Other References:
HUANG YUAN-YU , LIANG ZI-CAI: "Asialoglycoprotein Receptor and Its Application in Liver-targeted Drug Delivery", PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, vol. 42, no. 6, 1 June 2015 (2015-06-01), pages 501 - 510, XP055418689, DOI: 10.16476/j.pibb.2015.0028
MERWIN J. R., ET AL.: "TARGETED DELIVERY OF DNA USING YEE(GALNACAH)3, A SYNTHETIC GLYCOPEPTIDE LIGAND FOR THE ASIALOGLYCOPROTEIN RECEPTOR.", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 05., no. 06., 1 November 1994 (1994-11-01), US, pages 612 - 620., XP000484176, ISSN: 1043-1802, DOI: 10.1021/bc00030a017
PRAMFALK C ET AL., BIOCHIM BIOPHYS ACTA, vol. 1812, pages 929 - 937
PERRA A ET AL., FASEB J, vol. 22, pages 2981 - 2989
GARY J ET AL., ENDOCRINOLOGY, vol. 2000, no. 4, pages 1656 - 1661
See also references of EP 4086267A4
MERWIN J. R., ET AL.: "TARGETED DELIVERY OF DNA USING YEE(GALNACAH)3, A SYNTHETIC GLYCOPEPTIDE LIGAND FOR THE ASIALOGLYCOPROTEIN RECEPTOR.", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 05., no. 06., 1 November 1994 (1994-11-01), US, pages 612 - 620., XP000484176, ISSN: 1043-1802, DOI: 10.1021/bc00030a017
PRAMFALK C ET AL., BIOCHIM BIOPHYS ACTA, vol. 1812, pages 929 - 937
PERRA A ET AL., FASEB J, vol. 22, pages 2981 - 2989
GARY J ET AL., ENDOCRINOLOGY, vol. 2000, no. 4, pages 1656 - 1661
See also references of EP 4086267A4
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