LOW DENSITY LIPROTEIN BINDING PROTEINS AND THEIR USE IN DIAGNOSING AND TREATING ATHEROSCLEROSIS

WIPO Patent Application WO2001064874

A9

Isolated polynucleotides encoding polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

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LEES ANN M (US)
LEES ROBERT S (US)
LAW SIMON W (US)
ARJONA ANIBAL A (US)

PCT/US2001/006356

February 06, 2003

February 28, 2001

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BOSTON HEART FOUNDATION INC (US)
LEES ANN M (US)
LEES ROBERT S (US)
LAW SIMON W (US)
ARJONA ANIBAL A (US)

G01N33/50; A61K35/74; A61K35/76; A61K36/00; A61K38/00; A61K39/00; A61K39/39; A61K39/395; A61K45/00; A61K48/00; A61K49/00; A61P9/10; C07K14/47; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; G01N33/68; G01N33/92; (IPC1-7): C12N15/12; C07K14/47; C07K7/08; C07K16/18; C12Q1/68; A61K38/04; A61K38/17; A61K39/00; G01N33/53; G01N33/68

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