Title:
LUNG SURFACTANT COMPOSITIONS WITH DYNAMIC SWELLING BEHAVIOUR
Document Type and Number:
WIPO Patent Application WO2002017878
Kind Code:
A8
Abstract:
Lung surfactant compositions capable of forming a dynamic swelling phase when dispersed in a medium containing electrolytes. The dynamic swelling process can be observed by polarising microscopy and results in formation of a birefringerent network or tubules at an air/liquid interface. The dynamic swelling process results in a spreading of the lung surfactant over an increased surface area compared to the spreading of the lung surfactant in a non-dynamic swelling phase. The spreading takes place during a specific span of time after dispersion of a lung surfactant in e.g. a physiological electrolyte solution. Hereby, a more active spreading of the lung surfactant into the alveoli can be obtained after administration to the lungs, which in turn opens the possibility to use such a composition as a carrier for therapeutically, prophylactically and/or diagnostically active substances into the lungs or other organs or body areas that are hard to access. A lung surfactant composition of the invention comprises a lung surfactant, which - when dispersed as powder or particles in 0.9 % w/w sodium chloride in a concentration 10 % w/w at ambient temperature - is capable of forming, in the course of swelling, a birefringent network or tubules at an air-liquid-solid interface within a time period of from about 0.5 min to about 120 min.as observed by polarising microscopy.
Inventors:
LARSSON MARCUS (SE)
LARSSON KARE (SE)
WOLLMER PER (SE)
LACHMANN BURKHARD (NL)
HAITSMA JOHANNES JACOBUS (NL)
LARSSON KARE (SE)
WOLLMER PER (SE)
LACHMANN BURKHARD (NL)
HAITSMA JOHANNES JACOBUS (NL)
Application Number:
PCT/IB2001/001609
Publication Date:
December 18, 2003
Filing Date:
August 31, 2001
Export Citation:
Assignee:
LARSSON MARCUS (SE)
LARSSON KARE (SE)
WOLLMER PER (SE)
LACHMANN BURKHARD (NL)
HAITSMA JOHANNES JACOBUS (NL)
LARSSON KARE (SE)
WOLLMER PER (SE)
LACHMANN BURKHARD (NL)
HAITSMA JOHANNES JACOBUS (NL)
International Classes:
A61K9/00; A61K47/02; A61K9/72; A61K38/00; A61K45/00; A61K47/12; A61K47/24; A61K47/42; A61K47/44; A61M11/00; A61M15/00; A61P9/12; A61P11/00; A61P11/06; A61P11/08; A61P11/16; A61P19/04; A61P35/00; A61P41/00; A61P43/00; (IPC1-7): A61K9/00
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