Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
LYOPHILIZED PREPARATION OF VACCINE CONTAINING ALUMINUM ADJUVANT AND PREPARATION METHOD AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/073660
Kind Code:
A1
Abstract:
A lyophilized preparation of a vaccine containing an aluminum adjuvant, and a preparation method and a use therefor. The aluminum salt vaccine lyophilized preparation contains: a vaccine antigen, an adjuvant, a lyoprotectant, and a nanoparticle or a microparticle formed from compounding of an anionic polymer or a derivative thereof with an aluminum salt. The lyophilization method avoids large amounts of aggregation of aluminum hydroxide in the vaccine, and reduces reduction to antigen activity. The present invention is able to improve the stability of a vaccine in a lyophilization process and a storage process, and can cause the vaccine to not require cold-chain transportation. The invention is low cost, saves energy, and particularly solves the technical problem of difficulty in guaranteeing cold-chain delivery in remote areas.

Inventors:
SUN XUN (CN)
ZHANG ZHIRONG (CN)
GONG TAO (CN)
BAI SHUTING (CN)
HOU YINGYING (CN)
Application Number:
PCT/CN2020/136152
Publication Date:
April 22, 2021
Filing Date:
December 14, 2020
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV SICHUAN (CN)
International Classes:
A61K9/19; A61K39/39; A61K47/26; A61K47/36
Foreign References:
CN104587464A2015-05-06
US3743720A1973-07-03
CN1188418A1998-07-22
CN101959527A2011-01-26
Other References:
ZHAO, XIAOLIN, LI DEJUAN, CHEN WANGE, LUO XUAN, CAI YAN, JIN LIJIE: "Preparation of Lyophilized Reference Material for Recombinant Hepatitis B Vaccine (CHO Cells)", CHINESE JOURNAL OF BIOLOGICALS, vol. 19, no. 2, 1 February 2006 (2006-02-01), pages 1 - 2, XP055802383, DOI: 10.13200/j.cjb.2006.02.105.zhaoxl.032
WESTFALL JENNIFER, YATES JENNIFER L., VAN SLYKE GRETA, EHRBAR DYLAN, MEASEY THOMAS, STRAUBE RICHARD, DONINI OREOLA, MANTIS NICHOLA: "Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 36, no. 40, 1 September 2018 (2018-09-01), AMSTERDAM, NL, pages 5967 - 5976, XP055802356, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2018.08.059
Attorney, Agent or Firm:
BEIJING RUN ZEHENG INTELLECTUAL PROPERTY LAW FIRM (CN)
Download PDF: