Title:
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO/2018/149419
Kind Code:
A1
Abstract:
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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Inventors:
SMITH PETER (US)
ROBERTS TUCKER (US)
HIGUCHI ROBERT (US)
PARASELLI PRASUNA (US)
KOEHLER MICHAEL (US)
SCHWARZ JACOB (US)
CRAWFORD JAMES (US)
LY CUONG Q (US)
HANAN EMILY (US)
HU HUIYONG (US)
CHEN YONGSHENG (CN)
YU ZHIYONG (CN)
ROBERTS TUCKER (US)
HIGUCHI ROBERT (US)
PARASELLI PRASUNA (US)
KOEHLER MICHAEL (US)
SCHWARZ JACOB (US)
CRAWFORD JAMES (US)
LY CUONG Q (US)
HANAN EMILY (US)
HU HUIYONG (US)
CHEN YONGSHENG (CN)
YU ZHIYONG (CN)
Application Number:
PCT/CN2018/076957
Publication Date:
August 23, 2018
Filing Date:
February 22, 2018
Export Citation:
Assignee:
RQX PHARMACEUTICALS INC (US)
GENENTECH INC (US)
GENENTECH INC (US)
International Classes:
C07D245/04; A61K31/395; A61P31/04
Domestic Patent References:
| WO2017084630A1 | 2017-05-26 | |||
| WO2017084629A1 | 2017-05-26 | |||
| WO2015179441A2 | 2015-11-26 | |||
| WO2014081886A1 | 2014-05-30 | |||
| WO2013138187A1 | 2013-09-19 | |||
| WO2012166665A2 | 2012-12-06 | |||
| WO2011112441A1 | 2011-09-15 | |||
| WO2012036907A2 | 2012-03-22 | |||
| WO2014081886A1 | 2014-05-30 |
Foreign References:
| CN103788176A | 2014-05-14 |
Other References:
GREENE, T.W.WUTS, P. G. M.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
LIT ET AL.: "Salt Selection for Basic Drugs", INT J. PHARM., vol. 33, 1986, pages 201 - 217
"Design of Prodrugs", 1985, ELSEVIER
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
"March's Advanced Organic Chemistry", JOHN WILEY AND SONS
See also references of EP 3583096A4
LIT ET AL.: "Salt Selection for Basic Drugs", INT J. PHARM., vol. 33, 1986, pages 201 - 217
"Design of Prodrugs", 1985, ELSEVIER
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
"March's Advanced Organic Chemistry", JOHN WILEY AND SONS
See also references of EP 3583096A4
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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