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Patent Searching and Data


Title:
MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2019/035914
Kind Code:
A8
Abstract:
The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Inventors:
BRADY PATRICK (US)
BRAJE WILFRIED (DE)
DAI YUJIA (US)
DOHERTY GEORGE (US)
GONG JANE (US)
JANTOS KATJA (DE)
JI CHENG (US)
JUDD ANDREW (US)
KUNZER AARON (US)
MASTRACCHIO ANTHONY (US)
RISI ROBERTO (US)
SONG XIAOHONG (US)
SOUERS ANDREW (US)
SULLIVAN GERARD (US)
TAO ZHI-FU (US)
TESKE JESSE (US)
WANG XILU (US)
WENDT MICHAEL (US)
YU YIYUN (US)
ZHU GUIDONG (US)
PENNING THOMAS (US)
LAI CHUNQUI (US)
KLING ANDREAS (DE)
POHLKI FRAUKE (DE)
POTIN DOMINIQUE (FR)
GUILLIER FABRICE (FR)
Application Number:
US2018/000183
Publication Date:
September 19, 2019
Filing Date:
August 15, 2018
Export Citation:
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Assignee:
ABBVIE INC (US)
ABBVIE DEUTSCHLAND (DE)
BRADY PATRICK (US)
BRAJE WILFRIED (DE)
DAI YUJIA (US)
DOHERTY GEORGE (US)
GONG JANE (US)
JANTOS KATJA (DE)
JI CHENG (US)
JUDD ANDREW (US)
KUNZER AARON (US)
MASTRACCHIO ANTHONY (US)
RISI ROBERTO (US)
SONG XIAOHONG (US)
SOUERS ANDREW (US)
SULLIVAN GERARD (US)
TAO ZHI FU (US)
TESKE JESSE (US)
WANG XILU (US)
WENDT MICHAEL (US)
YU YIYUN (US)
ZHU GUIDONG (US)
PENNING THOMAS (US)
LAI CHUNQUI (US)
KLING ANDREAS (DE)
POHLKI FRAUKE (DE)
POTIN DOMINIQUE (FR)
GUILLIER FABRICE (FR)
International Classes:
A61K31/395; A61P35/00; C07D515/22
Attorney, Agent or Firm:
JOHANNES, Laura, E. (US)
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