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Title:
MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2020/147802
Kind Code:
A1
Abstract:
Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

Inventors:
CHEN JIANYONG (CN)
ZHOU YUNLONG (CN)
TANG GUOZHI (CN)
WU CHENGZHE (CN)
ZHAO LEILEI (CN)
JIAO LINGLING (CN)
SHENG BINGHUA (CN)
WANG SHAOMENG (US)
YANG CHAO-YIE (US)
CHEN HAO (CN)
HU WENLIANG (CN)
JING YU (CN)
Application Number:
CN2020/072565
Publication Date:
July 23, 2020
Filing Date:
January 17, 2020
Export Citation:
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Assignee:
ASCENTAGE PHARMA SUZHOU CO LTD (CN)
UNIV MICHIGAN REGENTS (US)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
International Classes:
C07D513/20; A61K31/553; A61P35/00; C07D498/08; C07D515/20
Domestic Patent References:
WO2017147410A12017-08-31
WO2018183418A12018-10-04
WO2016033486A12016-03-03
WO2019046150A12019-03-07
WO2019036575A12019-02-21
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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