Title:
MACROLIDE COMPOUND AND ITS USE OF TREATMENT CHRONIC RESPIRATORY DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/138847
Kind Code:
A1
Abstract:
Provided herein is macrolide compound and its use of treatment chronic respiratory disease. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers and application thereof. The compounds are useful for treating chronic respiratory disease.
Inventors:
LUO YING (CN)
YE YANPING (CN)
YU JIANGUO (CN)
YE YANPING (CN)
YU JIANGUO (CN)
Application Number:
PCT/CN2020/070981
Publication Date:
July 15, 2021
Filing Date:
January 08, 2020
Export Citation:
Assignee:
BEIJING CONTINENT PHARMACEUTICALS CO LTD (CN)
International Classes:
C07H17/08; A61K31/7048; A61P11/00
Domestic Patent References:
| WO2014166503A1 | 2014-10-16 | |||
| WO2014166503A1 | 2014-10-16 | |||
| WO2004013153A2 | 2004-02-12 | |||
| WO2001060833A2 | 2001-08-23 |
Foreign References:
| US20090076253A1 | 2009-03-19 | |||
| CN101203227A | 2008-06-18 |
Other References:
NICOLAS LETOURNEAU; PAVAN VIMAL; DOROTA KLEPACKI; ALEXANDER MANKIN; ARTEM MELMAN;: "Synthesis and antibacterial activity of desosamine-modified macrolide derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,, ELSEVIER, AMSTERDAM, NL, vol. 22, no. 14, 29 May 2012 (2012-05-29), AMSTERDAM, NL, pages 4575 - 4578, XP028504404, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2012.05.110
KEICHOA NAOTO, KUDOH SHOJI, YOTSUMOTO HIDEKI, AKAGAWA KIYOKO S.: "Erythromycin promotes monocyte to macrophage differentiation", THE JOURNAL OF ANTIBIOTICS, vol. 47, no. 1, 1 January 1994 (1994-01-01), pages 80 - 89, XP055827016
SUNAZUKA TOSHIAKI, HAJIME TAKIZAWA, MASASHI DESAKI, KUNIHIKO SUZUKI, RIKA OBATA, KAZUHIKO OTOGURO, SATOSHI OMURA: "Effects of Erythromycin and Its Derivatives on Interleukin-8 Release by Human Bronchial Epithelial Cell Line BEAS-2B Cells", THE JOURNAL OF ANTIBIOTICS, vol. 52, no. 1, 1 January 1999 (1999-01-01), pages 71 - 74, XP055827014
URSULA SCHELL, STEPHEN F. HAYDOCK, ANDREW L. KAJA, ISABELLE CARLETTI, RACHEL E. LILL, ELIOT READ, LESLEY S. SHEEHAN, LINDSEY LOW, : "Engineered biosynthesis of hybrid macrolide polyketides containing d-angolosamine and d-mycaminose moieties", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 6, no. 18, 1 January 2008 (2008-01-01), pages 3315, XP055364954, ISSN: 1477-0520, DOI: 10.1039/b807914e
SAULNIER, MGFRENNESSON, DBDESHPANDE, MSHANSEL, SBVYSA, DM, BIOORG.MED.CHEM LETT., vol. 4, 1994, pages 1985 - 1990
GREENWALD, RBCHOE, YHCONOVER, CDSHUM, K.WU, D.ROYZEN, M., J.MED.CHEM., vol. 43, 2000, pages 475
See also references of EP 4051687A4
KEICHOA NAOTO, KUDOH SHOJI, YOTSUMOTO HIDEKI, AKAGAWA KIYOKO S.: "Erythromycin promotes monocyte to macrophage differentiation", THE JOURNAL OF ANTIBIOTICS, vol. 47, no. 1, 1 January 1994 (1994-01-01), pages 80 - 89, XP055827016
SUNAZUKA TOSHIAKI, HAJIME TAKIZAWA, MASASHI DESAKI, KUNIHIKO SUZUKI, RIKA OBATA, KAZUHIKO OTOGURO, SATOSHI OMURA: "Effects of Erythromycin and Its Derivatives on Interleukin-8 Release by Human Bronchial Epithelial Cell Line BEAS-2B Cells", THE JOURNAL OF ANTIBIOTICS, vol. 52, no. 1, 1 January 1999 (1999-01-01), pages 71 - 74, XP055827014
URSULA SCHELL, STEPHEN F. HAYDOCK, ANDREW L. KAJA, ISABELLE CARLETTI, RACHEL E. LILL, ELIOT READ, LESLEY S. SHEEHAN, LINDSEY LOW, : "Engineered biosynthesis of hybrid macrolide polyketides containing d-angolosamine and d-mycaminose moieties", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 6, no. 18, 1 January 2008 (2008-01-01), pages 3315, XP055364954, ISSN: 1477-0520, DOI: 10.1039/b807914e
SAULNIER, MGFRENNESSON, DBDESHPANDE, MSHANSEL, SBVYSA, DM, BIOORG.MED.CHEM LETT., vol. 4, 1994, pages 1985 - 1990
GREENWALD, RBCHOE, YHCONOVER, CDSHUM, K.WU, D.ROYZEN, M., J.MED.CHEM., vol. 43, 2000, pages 475
See also references of EP 4051687A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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