Title:
MACROLIDE LHRH ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO1999050275
Kind Code:
A3
Abstract:
Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11, 12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.
Inventors:
SAUER DARYL R
HAVIV FORTUNA
RANDOLPH JOHN
MORT NICHOLAS A
DALTON CHRISTOPHER R
BRUNCKO MILAN
KAMINSKI MICHELE A
CRAWFORD BRADLEY W
FREY LISA MARIE
GREER JONATHON
HAVIV FORTUNA
RANDOLPH JOHN
MORT NICHOLAS A
DALTON CHRISTOPHER R
BRUNCKO MILAN
KAMINSKI MICHELE A
CRAWFORD BRADLEY W
FREY LISA MARIE
GREER JONATHON
Application Number:
PCT/US1999/004658
Publication Date:
February 22, 2001
Filing Date:
March 11, 1999
Export Citation:
Assignee:
ABBOTT LAB (US)
International Classes:
A61K31/7042; A61K31/7048; A61K31/7056; A61P5/24; A61P13/08; A61P15/00; A61P35/00; A61P43/00; C07H17/08; (IPC1-7): C07H17/08; A61K31/70
Domestic Patent References:
| WO1997021704A1 | 1997-06-19 | |||
| WO1997042206A1 | 1997-11-13 |
Foreign References:
| EP0487411A1 | 1992-05-27 | |||
| EP0716093A1 | 1996-06-12 | |||
| EP0559896A1 | 1993-09-15 |
Other References:
FERNANDES, PRABHAVATHI B. ET AL: "New macrolides active against Streptococcus pyogenes with inducible or constitutive type of macrolide - lincosamide - streptogramin B resistance", ANTIMICROB. AGENTS CHEMOTHER. (1989), 33(1), 78-81, XP002085920
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