Title:
MAGNOLOL AND SULFORAPHANE CONJUGATE, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/129747
Kind Code:
A1
Abstract:
Disclosed in the present invention are a magnolol and sulforaphane conjugate, and a preparation method therefor and use thereof. The magnolol and sulforaphane conjugate comprises C25H29NO2S2(CT-1), C25H29NO4S2(CT-2), and C25H29NO3S2(CT-3). By using a drug combination principle, the present invention achieves the first synthesis of the magnolol and sulforaphane conjugate (CT-1, CT-2, CT-3). By means of biological evaluation, the conjugate has an antitumor effect remarkably superior to that of magnolol and sulforaphane, has a broad spectrum of antitumor activity and strong druggability, is an antitumor compound having development potential, and also provides a new idea and way for development of a novel antitumor drug.
Inventors:
WU ZHENGZHI (CN)
TAO CHENG (CN)
CHEN JIAN (CN)
ZENG YONGCHANG (CN)
LIU JIEREN (CN)
LI LIMIN (CN)
TAO CHENG (CN)
CHEN JIAN (CN)
ZENG YONGCHANG (CN)
LIU JIEREN (CN)
LI LIMIN (CN)
Application Number:
PCT/CN2020/139058
Publication Date:
July 01, 2021
Filing Date:
December 24, 2020
Export Citation:
Assignee:
SHENZHEN INST GERIATRICS (CN)
WU ZHENGZHI (CN)
WU ZHENGZHI (CN)
International Classes:
C07C331/20; A61P35/00
Foreign References:
| CN103127039A | 2013-06-05 | |||
| CN106924225A | 2017-07-07 | |||
| CN107098832A | 2017-08-29 | |||
| CN111269161A | 2020-06-12 |
Other References:
LIN, S.YLIU, J.DCHANG, H.C.: "Magnolol Suppresses Proliferation of Cultured Human Colon and Liver Cancer Cells by Inhibiting DNA Synthesis and Activating Apotosis", J]. J. CELL BIOCHEM., vol. 84, 2002, pages 532 - 544
TANG, H.ZHANG, YLI, D.: "Discovery and Synthesis of Novel Magnolol Derivatives with Potent Anticancer Activity in Non-Small Cell Lung Cancer", J]. EUR. J. MED. CHEM., vol. 156, 2018, pages 190 - 205
SPRINGER T.A.: "Traffic Signals for Lymphocyte Recirculation and Leukocyte Emigration: the Multistep Paradigm", J]. CELL, vol. 76, 1994, pages 301 - 314, XP024245174, DOI: 10.1016/0092-8674(94)90337-9
See also references of EP 4083019A4
TANG, H.ZHANG, YLI, D.: "Discovery and Synthesis of Novel Magnolol Derivatives with Potent Anticancer Activity in Non-Small Cell Lung Cancer", J]. EUR. J. MED. CHEM., vol. 156, 2018, pages 190 - 205
SPRINGER T.A.: "Traffic Signals for Lymphocyte Recirculation and Leukocyte Emigration: the Multistep Paradigm", J]. CELL, vol. 76, 1994, pages 301 - 314, XP024245174, DOI: 10.1016/0092-8674(94)90337-9
See also references of EP 4083019A4
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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