Title:
MAMMALIAN PROTEIN PHOSPHATASES
Document Type and Number:
WIPO Patent Application WO2001046394
Kind Code:
A3
Abstract:
The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase hosphatase PTP's and STP's have been identified and their protein structure predicted.
More Like This:
Inventors:
PLOWMAN GREGORY D (US)
MARTINEZ RICARDO (US)
WHYTE DAVID (US)
MANNING GERARD (US)
SUDARSANAM SUCHA (US)
HILL RONALD J (US)
FLANAGAN PETER (US)
MARTINEZ RICARDO (US)
WHYTE DAVID (US)
MANNING GERARD (US)
SUDARSANAM SUCHA (US)
HILL RONALD J (US)
FLANAGAN PETER (US)
Application Number:
PCT/US2000/034736
Publication Date:
May 02, 2002
Filing Date:
December 21, 2000
Export Citation:
Assignee:
SUGEN INC (US)
PLOWMAN GREGORY D (US)
MARTINEZ RICARDO (US)
WHYTE DAVID (US)
MANNING GERARD (US)
SUDARSANAM SUCHA (US)
HILL RONALD J (US)
FLANAGAN PETER (US)
PLOWMAN GREGORY D (US)
MARTINEZ RICARDO (US)
WHYTE DAVID (US)
MANNING GERARD (US)
SUDARSANAM SUCHA (US)
HILL RONALD J (US)
FLANAGAN PETER (US)
International Classes:
G01N33/53; A61K45/00; A61P3/00; A61P3/10; A61P9/00; A61P9/02; A61P9/12; A61P15/08; A61P21/04; A61P25/00; A61P25/06; A61P25/16; A61P25/18; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/16; C12N15/09; C12N15/55; C12Q1/42; C12Q1/68; G01N33/566; (IPC1-7): C12N9/16; A61K38/46; C07K16/40; C12N15/55; C12Q1/42; C12Q1/68
Domestic Patent References:
| WO1997006245A1 | 1997-02-20 |
Other References:
KEYSE S M: "AN EMERGING FAMILY OF DUAL SPECIFICITY MAP KINASE PHOSPHATASES", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1265, 1995, pages 152 - 160, XP000196716, ISSN: 0167-4889
COHEN P T W: "Novel protein serine/threonine phosphatases: variety is the spice of life", TRENDS IN BIOCHEMICAL SCIENCES, vol. 22, no. 7, 1 July 1997 (1997-07-01), pages 245 - 251, XP004081591, ISSN: 0968-0004
HOOFT VAN HUIJSDUIJNEN R: "Protein tyrosine phosphatases: counting the trees in the forest", GENE, vol. 225, no. 1-2, 28 December 1998 (1998-12-28), pages 1 - 8, XP004153614, ISSN: 0378-1119
DATABASE EMBL 5 May 1999 (1999-05-05), NCI-CGAP: "wa98a11.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone", XP002167398
DATABASE EMBL 17 May 1999 (1999-05-17), MUZNY DM ET AL: "Homo sapiens chromosome 12 clone RP11-689B22", XP002167399
DATABASE EMBL 15 December 1998 (1998-12-15), MUDA M ET AL: "Dual specificity protein phosphatase 9 (Mitogen-activated protein kinase phosphtase 4)", XP002167400
DATABASE EMBL 24 May 1999 (1999-05-24), MUZNY DM ET AL: "Homo sapiens 12p BAC RP11-253I19", XP002175546
DATABASE EMBL 3 September 1998 (1998-09-03), WOESSNER J ET AL: "Homo sapiens full length insert cDNA clone YW04H08", XP002175547
DATABASE SWALL 1 February 1994 (1994-02-01), YI H ET AL: "Dual specificity protein phosphatase 2", XP002175548
DATABASE EMBL 4 April 1996 (1996-04-04), HILLIER L. ET AL: "zb04d10.s1 Soares_fetal_lung_NbHL19W Homo sapiens cDNA clone", XP002175549
DATABASE SWALL 1 October 1996 (1996-10-01), ISHIBASHI T ET AL: "Dual specificity protein phosphatase 3", XP002175550
DATABASE EMBL 15 December 1999 (1999-12-15), SMITH DR: "Homo sapiens chromosome 10 clone RP11-77G23", XP002175551
DATABASE EMBL 8 January 1998 (1998-01-08), HILLIER L ET AL: "zg88b02.s1 Soares_fetal-heart_NbHH19W Homo sapiens cDNA clone", XP002175552
DATABASE EMBL 23 June 1996 (1996-06-23), HILLIER L ET AL: "zd58b10.r1 Soares_fetal-heart_NbHH19W Homo sapiens cDNA clone", XP002175553
DATABASE EMBL 19 June 1998 (1998-06-19), NCI-CGAP: "ov60e06.x1 Soares_testis_NHT Homo sapiens cDNA clone", XP002175554
DATABASE SWALL 1 November 1999 (1999-11-01), THEODOSIOU A ET AL: "Dual specificity phosphatase MKP-5", XP002175555
DATABASE EMBL 11 March 1999 (1999-03-11), STOTHARD PM & D PILGRIM: "Mus musculus clone mouse1-9 putative protein phosphatase type 2C mRNA", XP002175556
DATABASE SWALL 1 May 1999 (1999-05-01), STOTHARD PM & D PILGRIM: "Hypothetical 18.9 kDa protein", XP002175557
DATABASE EMBL 10 November 1993 (1993-11-10), LAWSON JE ET AL: "Bos taurus pyruvate dehydrogenase phosphatase mRNA", XP002175558
DATABASE SWALL 1 June 1994 (1994-06-01), LAWSON JE ET AL: "Pyruvate dehydrogenase phosphatase, catalytic subunit 1", XP002175559
DATABASE EMBL 13 April 1995 (1995-04-13), MAURO LJ ET AL: "Rattus norwegicus protein tyrosine phosphatase mRNA", XP002175560
DATABASE GENESEQ 29 December 1998 (1998-12-29), DAVIS AR ET AL: "Mutant osteotesticular protein tyrosine phosphatase protein", XP002175561
COHEN P T W: "Novel protein serine/threonine phosphatases: variety is the spice of life", TRENDS IN BIOCHEMICAL SCIENCES, vol. 22, no. 7, 1 July 1997 (1997-07-01), pages 245 - 251, XP004081591, ISSN: 0968-0004
HOOFT VAN HUIJSDUIJNEN R: "Protein tyrosine phosphatases: counting the trees in the forest", GENE, vol. 225, no. 1-2, 28 December 1998 (1998-12-28), pages 1 - 8, XP004153614, ISSN: 0378-1119
DATABASE EMBL 5 May 1999 (1999-05-05), NCI-CGAP: "wa98a11.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone", XP002167398
DATABASE EMBL 17 May 1999 (1999-05-17), MUZNY DM ET AL: "Homo sapiens chromosome 12 clone RP11-689B22", XP002167399
DATABASE EMBL 15 December 1998 (1998-12-15), MUDA M ET AL: "Dual specificity protein phosphatase 9 (Mitogen-activated protein kinase phosphtase 4)", XP002167400
DATABASE EMBL 24 May 1999 (1999-05-24), MUZNY DM ET AL: "Homo sapiens 12p BAC RP11-253I19", XP002175546
DATABASE EMBL 3 September 1998 (1998-09-03), WOESSNER J ET AL: "Homo sapiens full length insert cDNA clone YW04H08", XP002175547
DATABASE SWALL 1 February 1994 (1994-02-01), YI H ET AL: "Dual specificity protein phosphatase 2", XP002175548
DATABASE EMBL 4 April 1996 (1996-04-04), HILLIER L. ET AL: "zb04d10.s1 Soares_fetal_lung_NbHL19W Homo sapiens cDNA clone", XP002175549
DATABASE SWALL 1 October 1996 (1996-10-01), ISHIBASHI T ET AL: "Dual specificity protein phosphatase 3", XP002175550
DATABASE EMBL 15 December 1999 (1999-12-15), SMITH DR: "Homo sapiens chromosome 10 clone RP11-77G23", XP002175551
DATABASE EMBL 8 January 1998 (1998-01-08), HILLIER L ET AL: "zg88b02.s1 Soares_fetal-heart_NbHH19W Homo sapiens cDNA clone", XP002175552
DATABASE EMBL 23 June 1996 (1996-06-23), HILLIER L ET AL: "zd58b10.r1 Soares_fetal-heart_NbHH19W Homo sapiens cDNA clone", XP002175553
DATABASE EMBL 19 June 1998 (1998-06-19), NCI-CGAP: "ov60e06.x1 Soares_testis_NHT Homo sapiens cDNA clone", XP002175554
DATABASE SWALL 1 November 1999 (1999-11-01), THEODOSIOU A ET AL: "Dual specificity phosphatase MKP-5", XP002175555
DATABASE EMBL 11 March 1999 (1999-03-11), STOTHARD PM & D PILGRIM: "Mus musculus clone mouse1-9 putative protein phosphatase type 2C mRNA", XP002175556
DATABASE SWALL 1 May 1999 (1999-05-01), STOTHARD PM & D PILGRIM: "Hypothetical 18.9 kDa protein", XP002175557
DATABASE EMBL 10 November 1993 (1993-11-10), LAWSON JE ET AL: "Bos taurus pyruvate dehydrogenase phosphatase mRNA", XP002175558
DATABASE SWALL 1 June 1994 (1994-06-01), LAWSON JE ET AL: "Pyruvate dehydrogenase phosphatase, catalytic subunit 1", XP002175559
DATABASE EMBL 13 April 1995 (1995-04-13), MAURO LJ ET AL: "Rattus norwegicus protein tyrosine phosphatase mRNA", XP002175560
DATABASE GENESEQ 29 December 1998 (1998-12-29), DAVIS AR ET AL: "Mutant osteotesticular protein tyrosine phosphatase protein", XP002175561
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