Title:
MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2014/165107
Kind Code:
A3
Abstract:
The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I) The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.
Inventors:
DIETRICH EVELYNE (CA)
POISSON CARL (CA)
GALLANT MICHEL (CA)
LESSARD STEPHANIE (CA)
LIU BINGCAN (CA)
DAS SANJOY KUMAR (CA)
RAMTOHUL YEEMAN (CA)
REDDY THUMKUNTA JAGADEESWAR (CA)
MARTEL JULIEN (CA)
VALLEE FREDERIC (CA)
LEVESQUE JEAN-FRANCOIS (CA)
POISSON CARL (CA)
GALLANT MICHEL (CA)
LESSARD STEPHANIE (CA)
LIU BINGCAN (CA)
DAS SANJOY KUMAR (CA)
RAMTOHUL YEEMAN (CA)
REDDY THUMKUNTA JAGADEESWAR (CA)
MARTEL JULIEN (CA)
VALLEE FREDERIC (CA)
LEVESQUE JEAN-FRANCOIS (CA)
Application Number:
PCT/US2014/024411
Publication Date:
February 26, 2015
Filing Date:
March 12, 2014
Export Citation:
Assignee:
VERTEX PHARMA (US)
International Classes:
C07H15/18; A61K31/7034; C07D493/10; C07H15/20; C07H15/207; C07H15/22; C07H15/26
Domestic Patent References:
| WO2011050323A1 | 2011-04-28 | |||
| WO2012164074A1 | 2012-12-06 | |||
| WO2012109263A1 | 2012-08-16 | |||
| WO2011073112A2 | 2011-06-23 | |||
| WO2005089733A2 | 2005-09-29 |
Other References:
ZHENFU HAN ET AL: "Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 53, no. 12, 24 June 2010 (2010-06-24), pages 4779 - 4792, XP002620405, ISSN: 0022-2623, [retrieved on 20100527], DOI: 10.1021/JM100438S
TOBIAS KLEIN ET AL: "FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 53, no. 24, 23 December 2010 (2010-12-23), pages 8627 - 8641, XP002620404, ISSN: 0022-2623, [retrieved on 20101124], DOI: 10.1021/JM101011Y
TOBIAS KLEIN ET AL: "FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 53, no. 24, 23 December 2010 (2010-12-23), pages 8627 - 8641, XP002620404, ISSN: 0022-2623, [retrieved on 20101124], DOI: 10.1021/JM101011Y
Attorney, Agent or Firm:
CHE, Jennifer G. (50 Northern Avenue 15th Floo, Boston MA, US)
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