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Title:
MARKER GENE FOR IDENTIFYING AND CLASSIFYING DPC CELL, SCREENING METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/134225
Kind Code:
A1
Abstract:
Provided are a marker gene for identifying and classifying dopaminergic precursor cells (DPC), a screening method therefor and use thereof. The marker gene is a combination of 12 genes having specific up-regulation expression in the DPC cells relative to the neural stem cells (NSCs). The screening of the marker gene is based on a high-throughput RNA sequencing technology. In the samples of the NSC cells and the DPC cells, genes of which the specific expression is significantly up-regulated in the DPC cells are detected, and by bioinformatic analysis, a group of candidate genes capable of regulating the differentiation process of neural stem cells to dopaminergic neurons are identified. The marker gene combinations provided can be used to identify and classify DPC cell products for clinical treatment and to control the quality of the DPC cell products for clinical application.

Inventors:
CAI MENG (CN)
WEI JUN (CN)
Application Number:
PCT/CN2021/070593
Publication Date:
June 30, 2022
Filing Date:
January 07, 2021
Export Citation:
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Assignee:
IREGENE THERAPEUTICS LTD (CN)
International Classes:
C12Q1/6888; C12Q1/6809; C12Q1/6883
Domestic Patent References:
WO2012050627A22012-04-19
Foreign References:
CN110582578A2019-12-17
CN110499364A2019-11-26
CN109996895A2019-07-09
CN104962658A2015-10-07
CN108841949A2018-11-20
Other References:
PETRAGLIA FELICE: "Corticotropin Releasing Hormone: a Diagnostic Marker for Behavioral and Reproductive Disorders? ", FRONTIERS IN BIOSCIENCE, vol. 12, 31 January 2007 (2007-01-31), XP055945260
TIAN YYTANG CJWU JZHOU JS: "Parkinson's disease in China", NEUROL SCI, vol. 32, no. 1, February 2011 (2011-02-01), pages 23 - 30, XP019876404, DOI: 10.1007/s10072-010-0461-8
MALEK N: "Deep Brain Stimulation in Parkinson's Disease", NEUROL INDIA, vol. 67, no. 4, July 2019 (2019-07-01), pages 968 - 978
Attorney, Agent or Firm:
HANGZHOU WUZHOU PUHUA PATENT AGENCY FIRM ( SPECIAL GENERAL PARTNERSHIP) (CN)
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