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Title:
MARKER FOR PROGNOSIS OF PANCREATIC CANCER, KIT FOR DIAGNOSING PROGNOSIS OF PANCREATIC CANCER, AND METHOD FOR PREDICTING PROGNOSIS OF PANCREATIC CANCER
Document Type and Number:
WIPO Patent Application WO/2019/021654
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a cancer marker that has high sensitivity and specificity and can predict the "prognosis" of a pancreatic cancer patient. A marker for prognosis of pancreatic cancer according to the present invention is characterized by containing a combination of protein ITGB1 and protein PODXL and/or protein BCL7B. The present disclosure includes: a kit for diagnosing the prognosis of pancreatic cancer, characterized by comprising an antibody directed against protein ITGB1 and an antibody directed against protein PODXL and/or an antibody directed against protein BCL7B; and a method for predicting the prognosis of pancreatic cancer, characterized by comprising a step of measuring the immunohistochemistry score of each of protein ITGB1 and at least one protein selected from the group consisting of protein PODXL and protein BCL7B in a sample or the concentration of each of protein ITGB1 and at least one protein selected from the group consisting of protein PODXL and protein BCL7B in the sample.

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Inventors:
TANIUCHI KEISUKE (JP)
Application Number:
PCT/JP2018/022186
Publication Date:
January 31, 2019
Filing Date:
June 11, 2018
Export Citation:
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Assignee:
UNIV NAT CORP KOCHI UNIV (JP)
International Classes:
G01N33/574; C07K14/47; C07K14/705; C07K16/28; C07K16/30
Domestic Patent References:
WO2017098915A12017-06-15
WO2017022472A12017-02-09
WO2016049045A12016-03-31
Foreign References:
JP2017108686A2017-06-22
Other References:
TANIUCHI, K. ET AL.: "Podocalyxin-like protein, linked to poor prognosis of pancreatic cancers, promotes cell invasion by binding to gelsolin", CANCER SCIENCE, vol. 107, no. 10, 2 September 2016 (2016-09-02), pages 1430 - 1442, XP055677717
ANIUCHI, K. ET AL.: "BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling", AMERICAN JOURNAL OF CANCER RESEARCH, vol. 8, no. 3, 1 March 2018 (2018-03-01), pages 387 - 404, XP055677721
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
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