Title:
MASP-2 INHIBITORS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2019/231933
Kind Code:
A3
Abstract:
The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
Inventors:
METZ MARKUS (US)
GOLDSTEIN SARA REBECCA (US)
KESHIPEDDY SANTOSH KUMAR (US)
KWON DO YEON (US)
LEMUS ROBERT HUERTA (US)
VADDELA SUDHEER BABU (US)
CUTSHALL NEIL S (US)
GAGE JENNIFER LYNN (US)
GRUSWITZ FRANZ A (US)
KHALAF JUHIENAH (US)
LITTLE THOMAS L (US)
NGUYEN JEREMIAH H (US)
NOLLERT VON SPECHT PETER KURT (US)
TSOUNG JENNIFER (US)
CICIRELLI MICHAEL (US)
GOLDSTEIN SARA REBECCA (US)
KESHIPEDDY SANTOSH KUMAR (US)
KWON DO YEON (US)
LEMUS ROBERT HUERTA (US)
VADDELA SUDHEER BABU (US)
CUTSHALL NEIL S (US)
GAGE JENNIFER LYNN (US)
GRUSWITZ FRANZ A (US)
KHALAF JUHIENAH (US)
LITTLE THOMAS L (US)
NGUYEN JEREMIAH H (US)
NOLLERT VON SPECHT PETER KURT (US)
TSOUNG JENNIFER (US)
CICIRELLI MICHAEL (US)
Application Number:
PCT/US2019/034220
Publication Date:
July 30, 2020
Filing Date:
May 28, 2019
Export Citation:
Assignee:
OMEROS CORP (US)
METZ MARKUS (US)
GOLDSTEIN SARA REBECCA (US)
KESHIPEDDY SANTOSH KUMAR (US)
KWON DO YEON (US)
LEMUS ROBERT HUERTA (US)
VADDELA SUDHEER BABU (US)
METZ MARKUS (US)
GOLDSTEIN SARA REBECCA (US)
KESHIPEDDY SANTOSH KUMAR (US)
KWON DO YEON (US)
LEMUS ROBERT HUERTA (US)
VADDELA SUDHEER BABU (US)
International Classes:
C07D207/00; C07D205/00; C07D213/00
Domestic Patent References:
WO2004032834A2 | 2004-04-22 | |||
WO2000039124A1 | 2000-07-06 |
Foreign References:
US20060002937A1 | 2006-01-05 |
Other References:
HEJA ET AL.: "Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. Vol. 287, no. 24, 8 June 2012 (2012-06-08), pages 20290 - 20300, XP055285722, DOI: 10.1074/jbc.M112.354332
HARMAT ET AL.: "The Structure of MBL-associated Serine Protease-2 Reveals that Identical Substrate Specificities of C1s and MASP-2 are Realized Through Different Sets of Enzyme- Substrate Interactions", JMB, vol. 342, no. 5, 14 July 2004 (2004-07-14), XP004844933
SZAKACS ET AL.: "Novel MASP-2 inhibitors developed via directed evolution of human TFPI1 are potent lectin pathway inhibitors", J. BIOL. CHEM., vol. 294, no. 20, 5 April 2019 (2019-04-05), pages 8227 - 8237, XP055727499
HARMAT ET AL.: "The Structure of MBL-associated Serine Protease-2 Reveals that Identical Substrate Specificities of C1s and MASP-2 are Realized Through Different Sets of Enzyme- Substrate Interactions", JMB, vol. 342, no. 5, 14 July 2004 (2004-07-14), XP004844933
SZAKACS ET AL.: "Novel MASP-2 inhibitors developed via directed evolution of human TFPI1 are potent lectin pathway inhibitors", J. BIOL. CHEM., vol. 294, no. 20, 5 April 2019 (2019-04-05), pages 8227 - 8237, XP055727499
Attorney, Agent or Firm:
PHILLIPS, Eifion D. et al. (US)
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